{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:16:42Z","timestamp":1779002202342,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the occurrence of sudden sensorineural hearing loss following immunization with BNT162b2 (Comirnaty\u00ae; Pfizer BioNTech) or mRNA\u20101273 (Spikevax\u00ae; Moderna) to the occurrence among unvaccinated individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Nationwide Danish health care registers comprised all Danish residents living in Denmark on October 1, 2020, who were 18 years or older or turned 18 in 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the occurrence of sudden sensorineural hearing loss following immunization with BNT162b2 (Comirnaty\u00ae; Pfizer BioNTech) or mRNA\u20101273 (Spikevax\u00ae; Moderna) (first, second, or third dose) against unvaccinated person time. Secondary outcomes were a first\u2010ever hospital diagnosis of vestibular neuritis and a hearing examination, by an ear\u2010nose\u2010throat (ENT) specialist, followed by a prescription of moderate to high\u2010dose prednisolone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BNT162b2 or mRNA\u20101273 vaccine was not associated with an increased risk of receiving a discharge diagnosis of sudden sensorineural hearing loss (adjusted hazard ratio [HR]: 0.99, confidence interval [CI]: 0.59\u20101.64) or vestibular neuritis (adjusted HR: 0.94, CI: 0.69\u20101.24). We found a slightly increased risk (adjusted HR: 1.40,\u00a0CI, 1.08\u20101.81) of initiating moderate to high\u2010dose oral prednisolone following a visit to an ENT specialist within 21 days from receiving a messenger RNA (mRNA)\u2010based Covid\u201019 vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings do not suggest an increased risk of sudden sensorineural hearing loss or vestibular neuritis following mRNA\u2010based COVID\u201019 vaccination. mRNA\u2010Covid\u201019 vaccination may be associated with a small excess risk of a visit to an ENT specialist visit followed by a prescription of moderate to high doses of prednisolone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.394","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T04:11:05Z","timestamp":1686197465000},"page":"1472-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sudden Sensorineural Hearing Loss Following Immunization With BNT162b2 or mRNA\u20101273: A Danish Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-7187","authenticated-orcid":false,"given":"Per","family":"Damkier","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-6594","authenticated-orcid":false,"given":"Brian","family":"Cleary","sequence":"additional","affiliation":[{"name":"Pharmacy Department Rotunda Hospital Dublin Ireland"},{"name":"School of Pharmacy and Biomolecular Science Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-8708","authenticated-orcid":false,"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Odense University Hospital Odense Denmark"},{"name":"Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-1407","authenticated-orcid":false,"given":"Jesper H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Research Unit for ORL\u2013Head and\u00a0Neck Surgery and Audiology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-5358","authenticated-orcid":false,"given":"Louise","family":"Ladebo","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-9092","authenticated-orcid":false,"given":"Peter B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-6072","authenticated-orcid":false,"given":"Lars Christian","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Southern Denmark  Odense 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