{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:25:37Z","timestamp":1787739937142,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report cardiac outcomes after total thyroidectomy for amiodarone\u2010induced thyrotoxicosis according to the baseline left ventricular ejection fraction in a tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective, monocentric.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The tertiary health care system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent total thyroidectomy for amiodarone\u2010induced thyrotoxicosis between 2010 and 2020 with age &gt;18 and available preoperative left ventricular ejection fraction were included in this study. Patients were dichotomized into: group 1 with left ventricular ejection fraction \u226540% (mildly reduced\/normal ejection fraction), and group 2 with left ventricular ejection fraction &lt;40% (reduced ejection fraction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 34 patients in group 1 and 17 to group 2. The latter were younger (median 58.4 [Q1\u2010Q3 48.0\u201064.9] vs. 69.8 years in group 1 [59.8\u201078.3], <jats:italic>p<\/jats:italic>\u2009=\u2009.0035) and they presented more cardiomyopathy (58.8 vs. 26.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.030). Overall, the median time until surgery referral was 3.1 [1.9\u20107.1] months and 47.1% underwent surgery after restoration of euthyroidism. Surgical complications accounted for 7.8%. In group 2, the median left ventricular ejection fraction was significantly improved after surgery (22.5 [20.0\u201025.0] vs. 29.0% [25.3\u201045.5], <jats:italic>p<\/jats:italic>\u2009=\u2009.0078). Five\u2010year cardiac mortality was significantly higher in group 2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001): 47.0% died of cardiac causes versus 2.9% in group 1. A baseline left ventricular ejection fraction &lt;40% and a longer time until surgery referral were significantly associated with cardiac mortality (multivariable Cox regression analysis, <jats:italic>p<\/jats:italic>\u2009=\u2009.015 and .020, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results reinforce the idea that surgery, if chosen, should be performed quickly in patients with left ventricular ejection fraction &lt;40%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.405","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T02:14:35Z","timestamp":1686795275000},"page":"1542-1549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mortality After Total Thyroidectomy for Amiodarone\u2010Induced Thyrotoxicosis According to Left Ventricular Ejection Fraction"],"prefix":"10.1002","volume":"169","author":[{"given":"Samuel","family":"Frey","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne Institut des Maladies de l'Appareil Digestif Nantes France"},{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM l'institut du thorax Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Caillard","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne Institut des Maladies de l'Appareil Digestif Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Mahot","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service d'Endocrinologie, Diab\u00e9tologie et Nutrition l'institut du thorax Nantes 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