{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:45Z","timestamp":1790776425140,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effectiveness of platelet\u2010rich plasma (PRP) injection into the olfactory clefts of coronavirus disease 2019 (COVID\u201019) patients with persistent olfactory dysfunction (OD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From March 2022 to November 2022, COVID\u201019 patients with persistent OD were recruited from three European hospitals to undergo PRP injections into the olfactory clefts. Olfactory function was evaluated at baseline and 10 weeks postinjection with the Olfactory Disorder Questionnaire (ODQ) and threshold, discrimination, and identification (TDI) test. Data were compared with a control group of untreated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010one patients who underwent PRP injection and 78 controls were included. Sixty\u2010five PRP patients (80.3%) experienced subjective smell improvement after a mean duration of 3.4\u2009\u00b1\u20091.9 weeks. The parosmia, life quality statement, and ODQ sub\u2010 and total scores significantly decreased from pre\u2010 to 10\u2010week postinjection in the PRP group. The TDI sub\u2010 and total scores significantly increased 10 weeks postinjection. In controls, the ODQ score did not change over time, while the discrimination, identification, and total TDI scores significantly increase after 10 weeks of follow\u2010up. The 10\u2010week TDI and ODQ scores were significantly better in the PRP group compared with the controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients who underwent PRP injection reported better 10\u2010week subjective and objective smell outcomes than controls. Future randomized\u2010controlled studies using saline injection into the olfactory cleft of controls are needed to determine the superiority of PRP over placebo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.460","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T05:28:31Z","timestamp":1690781311000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effectiveness of Platelet\u2010Rich Plasma for COVID\u201019\u2010Related Olfactory Dysfunction: A Controlled Study"],"prefix":"10.1002","volume":"170","author":[{"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Polyclinic of Poitiers, Elsan Poitiers France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University) Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons) Mons Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU Saint\u2010Pierre Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi A.","family":"Vaira","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Operative Unit, Department of Medicine, Surgery and Pharmacy 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