{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:06:24Z","timestamp":1793383584640,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The influence of apnea\u2010 and hypopnea\u2010predominance on hypoglossal nerve stimulation therapy outcomes (HGNS) is still poorly defined. We assessed the significance of apnea\u2010 and hypopnea\u2010predominance in HGNS outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single\u2010institution tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 216 subjects were included, all of which had undergone drug\u2010induced sleep endoscopy (DISE) and HGNS implantation. Demographic and polysomnographic data were collected. The 4% apnea\u2010hypopnea criteria were used to calculate apnea\u2010hypopnea index (AHI). Central apneas were omitted. Univariate logistic and linear regression were used to study the association between these data and apnea\u2010predominance and hypopnea\u2010predominance. Kruskal\u2010Wallis rank sum test was used to compare medians between groups for DISE collapse patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three patients were apnea\u2010predominant, and 153 patients were hypopnea\u2010predominant. These 2 groups were similar demographically (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.20). There was no significant difference in HGNS outcomes between the groups assessed using Sher20 criteria at the 1\u2010year mark using all\u2010night, single\u2010setting polysomnography or home sleep studies. Apnea index (AI)\/AHI\u00a0and reduction in AHI from preoperative to titration were significantly associated (<jats:italic>p<\/jats:italic>\u2009=\u2009.046). The median preoperative\u00a0hypopnea index was significantly lower (<jats:italic>p<\/jats:italic>\u2009=\u2009.033) in subjects with no oropharyngeal collapse than patients with partial or complete oropharyngeal collapse. There were no significant relationships between AI\/AHI and the different degrees of collapse at the velopharynx, oropharynx, tongue base, or epiglottis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In line with CPAP, tonsillectomy, and mandibular advancement therapy studies, we found there was largely no significant difference in DISE anatomy or in HGNS treatment outcomes between apnea\u2010 and hypopnea\u2010predominant individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.464","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T03:33:46Z","timestamp":1691120026000},"page":"1674-1682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypoglossal Nerve Stimulation Therapy Outcomes in Apnea\u2010 Versus Hypopnea\u2010Predominant Patients"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8053-1378","authenticated-orcid":false,"given":"Thomas Z.","family":"Gao","sequence":"first","affiliation":[{"name":"College of Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University Wexner Medical Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Rings","sequence":"additional","affiliation":[{"name":"Boonshoft School of Medicine Wright State University Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zia","sequence":"additional","affiliation":[{"name":"College of Medicine and Life Sciences Toledo University Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah K.","family":"Harris","sequence":"additional","affiliation":[{"name":"College of Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene G.","family":"Chio","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University Wexner Medical Center Columbus OH 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