{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:56:31Z","timestamp":1784426191623,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of age and frailty on 30\u2010day outcomes following surgery for oral squamous cavity carcinoma (OSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cross\u2010sectional analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>American College of Surgeons' National Quality Improvement Program (NSQIP) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent OSCC resection were queried via NSQIP (2015\u20102020). Cases were stratified by age (18\u201065, 65\u201075, and older than 75) as well as by modified frailty index scores (mFI 0, mFI 1, and mFI 2+) for comparative analyses. Univariate and multivariable analyses were conducted to examine demographics, perioperative outcomes, and 30\u2010day postoperative adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3238 patients who underwent OSCC surgery were identified and categorized as nongeriatric (\u201cNGA,\u201d age 18\u201065), younger geriatric (\u201cYGA,\u201d age 65\u201075), and older geriatric (\u201cOGA,\u201d age &gt;75) adults. Compared to NGA, geriatric patients had higher the American Society of Anesthesiologists classification, higher modified frailty index scores, and more comorbidities such as hypertension, congestive heart failure, chronic obstructive disease, and diabetes (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). YGAs and OGAs were also less likely to undergo neck dissection (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), composite resection (<jats:italic>p<\/jats:italic>\u2009=\u2009.006), and free flap reconstruction compared to NGAs (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). When controlling for confounders, age was not independently associated with an increased risk of poor outcomes. On the other hand, frailty was found to be independently associated with a higher risk of adverse events (odds ratio: 1.40 [1.15\u20101.70], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for mFI 1, odds ratio: 1.45 [1.04\u20102.02], <jats:italic>p<\/jats:italic>\u2009=\u2009.027 for mFI 2+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A higher mFI score, not older age, is associated with an increased risk of 30\u2010day complications following OSCC surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.476","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:21:43Z","timestamp":1692429703000},"page":"1523-1532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Age and Frailty With 30\u2010Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-5893","authenticated-orcid":false,"given":"Trinithas","family":"Boyi","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samipya","family":"Kafle","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery Yale University School of Medicine New Haven Connecticut 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