{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:25:31Z","timestamp":1783736731503,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study sought to analyze the efficacy and safety of postoperative prednisone to reduce reliance on opioids in adult benign oropharyngeal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single tertiary\u2010care facility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing tonsillectomy (T), tonsillectomy and adenoidectomy (T&amp;A), and\/or modified uvulopalatopharyngoplasty (UPPP) from December 2020 to January 2023 received the standard of care postoperative management. A prednisone taper was dependent on surgeon preference. Cohorts were based on the prescription of postoperative steroids. Patients completed a survey to assess opioid usage, pain scores, and steroid compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two patients were included. The nonsteroid cohort (N\u2009=\u200929) received an average of 467\u2009\u00b1\u200994.1 morphine milligram equivalents (MME), and the steroid cohort (N\u2009=\u200943) received an average of 285\u2009\u00b1\u2009128 MME (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The nonsteroid cohort consumed 1.62 times more opioids than the steroid cohort (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.002). There were no significant differences in complication or refill rates between treatment groups. There were no significant differences in pain scores on the day of surgery or postoperative days\u00a01, 5, or 10 (<jats:italic>P<\/jats:italic>\u2009=\u20090.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.66, <jats:italic>P<\/jats:italic>\u2009=\u20090.62, and <jats:italic>P<\/jats:italic>\u2009=\u20090.22, respectively). Patients undergoing T&amp;A (<jats:italic>p<\/jats:italic>\u2009=\u20090.019) or who had current psychiatric medication use (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.006) consumed significantly more opioids. Patients who received a total opioid prescription of &gt;300 MME\u00a0(40 5\u2010mL doses of 5\u2009mg\/5\u2009mL liquid oxycodone) consumed 2.27 times more postoperative opioids than patients with opioid prescriptions \u2264300 MME (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients who did not receive steroids consumed 1.62 times more postoperative opioids compared to those who completed a steroid taper. Corticosteroid use was not associated with changes in pain scores, refill rates, or complication rates and may be considered in a multimodal approach to pain management in adults undergoing benign oropharyngeal surgery, although further study is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.515","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:41:36Z","timestamp":1694583696000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prednisone Decreases Opioid Use in Adults Undergoing Benign Oropharyngeal Surgery"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-3024","authenticated-orcid":false,"given":"Joann M.","family":"Butkus","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-3277","authenticated-orcid":false,"given":"Emily S.","family":"Sagalow","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-9948","authenticated-orcid":false,"given":"Samuel","family":"Alfonsi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Riordan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-5899","authenticated-orcid":false,"given":"Brian","family":"McGettigan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5303-9748","authenticated-orcid":false,"given":"Maurits","family":"Boon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Huntley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Center for Disease Control and Prevention. Opioids. June 1 2022. Accessed July 18 2022.https:\/\/www.cdc.gov\/opioids\/index.html"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1251"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05016-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818757999"},{"issue":"25","key":"e_1_2_9_6_1","first-page":"S1","article-title":"Clinical practice guideline: opioid prescribing for analgesia after common otolarygnology operations","volume":"164","author":"Anne S","year":"2021","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27215"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28359"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2019.03.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-019-0352-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818757959"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103191"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894211053290"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002490"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.229"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2017.1034"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319866824"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002919"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002364"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419883296"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002674"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002709"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211045364"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29845"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211071116"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348211048846"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003264"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103093"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003405"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200205000-00025"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27872"},{"issue":"11","key":"e_1_2_9_33_1","first-page":"988","article-title":"Association of celecoxib use with decreased opioid requirements after head and neck cancer surgery with free tissue reconstruction","volume":"144","author":"Carpenter PS","year":"2018","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22506"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819832528"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819841885"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28402"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820947013"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2019.29014.new"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22941"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0282"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0987"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.09.051"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.4209"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15299"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03021038"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.8.917"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-020-02758-y"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613211000832"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27167"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024122"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2022.111434"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820973250"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922820944565"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110862"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1067-2516(99)80059-3"},{"key":"e_1_2_9_57_1","unstructured":"JackmanS.\u00a0pscl: classes and methods for R developed in the Political Science Computational Laboratory. United States Studies Centre University of Sydney. R package version 1.5.5. 2020. Accessed June 26 2023.https:\/\/github.com\/atahk\/pscl\/"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2011.02373.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00588.x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318159a5cc"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:22:43Z","timestamp":1760970163000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ohn.515"],"URL":"https:\/\/doi.org\/10.1002\/ohn.515","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"2023-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}