{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:46:19Z","timestamp":1769100379466,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to develop a novel method to classify different genioglossus (GG) responses to upper airway (UA) negative pressure in obstructive sleep apnea (OSA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A single\u2010center, prospective, cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sleep Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with OSA underwent drug\u2010induced sleep endoscopy with synchronous genioglossus electromyography (ggEMG) and UA pressure monitoring. In spontaneous obstructive apnea events, the value of epiglottis negative pressure at the end of inspiration (P<jats:sub>epi<\/jats:sub>) and corresponding peak phasic ggEMG were recorded as pairing data for linear regression analysis to classify GG response modes: peak phasic ggEMG\u2010P<jats:sub>epi<\/jats:sub> linear mode (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) were classified as group 1; others (<jats:italic>P<\/jats:italic>\u2009\u2265\u2009.05) were classified as group 2. Using nasopharyngeal tube (NPT) to reopen the palatopharyngeal cavity for comparing the improvement between the OSA patients with different GG response modes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty subjects were analyzed for GG response modes: 22 patients were in group 1 (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.233\u20100.867), and 38 patients were in group 2. The proportion of partial (63.16% vs 59.09%) or complete (36.84% vs 22.73%) collapse rate of the tongue base in group 2 was significantly higher (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20097.823, <jats:italic>P<\/jats:italic>\u2009=\u2009.020). The improvement of the apnea\u2010hypopnea index after NPT placement in group 2 was significantly lower than in group 1 (59.09% vs 31.58%, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20094.339, <jats:italic>P<\/jats:italic>\u2009=\u2009.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This novel method is advantageous for distinguishing OSA patients with different GG response abilities to UA negative pressure, whose GG responses conforming to peak phasic ggEMG\u2010P<jats:sub>epi<\/jats:sub> linear mode might be more suitable for palatopharyngeal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.525","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T01:57:35Z","timestamp":1695261455000},"page":"586-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Method to Classify the Responses of Genioglossus to Negative Pressure in OSA Patients"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-3400","authenticated-orcid":false,"given":"Yingqian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head Neck Surgery, Sleep Medicine Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing Changping People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head Neck Surgery, Sleep Medicine Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing Changping People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinkun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head Neck Surgery, Sleep Medicine Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing Changping People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head Neck Surgery, Sleep Medicine Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing Changping People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-6202","authenticated-orcid":false,"given":"Jingying","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head Neck Surgery, Sleep Medicine Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University  Beijing Changping People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/sbr.12098"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13616"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27497"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3600"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0156-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819840356"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0448OC"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.10.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00324.2002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.4.470"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.7.851"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S143296"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21841"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.072488"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01214.2007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00186.2019"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2016.1163418"},{"key":"e_1_2_10_20_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 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