{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:53:26Z","timestamp":1791939206024,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is a link between laryngopharyngeal reflux (LPR) and the formation of benign vocal fold lesions (BVFLs). However, previous studies have mainly focused on LPR suggested by symptoms and signs, rather than objectively diagnosed LPR via pharyngeal pH monitoring. We, therefore, conducted a Meta\u2010analysis to evaluate the association between pharyngeal pH monitoring diagnosed LPR and the odds of BVFLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Relevant observational studies were identified by searching PubMed, Embase, Cochrane Library, and Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>We evaluated between\u2010study heterogeneity using the Cochrane <jats:italic>Q<\/jats:italic> test and estimated the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic. Random\u2010effects models were used when significant heterogeneity was observed; otherwise, fixed\u2010effects models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen datasets from 9 studies were included. Among them, 493 were diagnosed with LPR and 344 had BVFLs. LPR was related to a higher odds of BVFLs (odds ratio: 3.26, 95% confidence interval: 1.84\u20105.76, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) with moderate heterogeneity (<jats:italic>P<\/jats:italic> for Cochrane <jats:italic>Q<\/jats:italic> test\u2009=\u2009.006, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200957%). Subgroup analyses showed that the association was similar in studies with only pharyngeal pH monitoring (Restech), with double\u2010probe or 3\u2010site pH monitoring, and with 24\u2010hour multichannel intraluminal impedance\u2010pH monitoring (<jats:italic>P<\/jats:italic> for subgroup difference\u2009=\u2009.15). In addition, subgroup analysis showed consistent results in studies from Asia and Europe (<jats:italic>P<\/jats:italic> for subgroup analysis\u2009=\u2009.12), and the association seemed to be consistent for vocal Reinke's edema, nodules, and polyps (<jats:italic>P<\/jats:italic> for subgroup difference\u2009=\u2009.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pharyngeal pH monitoring diagnosed LPR is associated with the formation of BVFLs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.529","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:04:21Z","timestamp":1695182661000},"page":"309-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"170","author":[{"given":"Quan\u2010Wei","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"},{"name":"Department of Otolaryngology Chongqing Traditional Chinese Medicine Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chongqing Traditional Chinese Medicine Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chongqing Traditional Chinese Medicine Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chongqing Traditional Chinese Medicine Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Lin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2020.11.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819827488"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000486"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S282809"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2021.08.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14728"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4142-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000536"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000408"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.08.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2019.03.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200312000-00009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27932"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5217-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13091643"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_19_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.2","author":"Higgins J","year":"2021"},{"key":"e_1_2_8_20_1","unstructured":"WellsGA SheaB O'ConnellD et al. 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