{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:57:15Z","timestamp":1786550235479,"version":"build-2736575974"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the American Joint Committee on Cancer (AJCC) 8th edition staging guidelines update, human papillomavirus\u2010positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) is now staged separately from its HPV\u2010negative counterpart, preventing meaningful comparison of cases staged with the 7th versus 8th edition criteria. Manual restaging is time\u2010consuming and error\u2010prone, hindering multiyear analyses for HPV+ OPSCC. We developed an automated computational tool for re\u2010classifying HPV+ OPSCC pathological and clinical tumor staging from AJCC 7th to 8th edition. The tool is designed to handle large data sets, ensuring comprehensive and accurate analysis of historic HPV+ OPSCC data. Validated against institutional and National Cancer Database data sets, the algorithm achieved accuracies of 100% (95% confidence interval [CI]\u00a098.8%\u2010100%) and 93.4% (95% CI\u00a093.1%\u201093.7%), successfully restaging 326\/326 and 26,505\/28,374 cases, respectively. With its open\u2010source design, this computational tool can enhance future HPV+ OPSCC research and inspire similar tools for other cancer types and subsequent AJCC editions.<\/jats:p>","DOI":"10.1002\/ohn.558","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T09:09:26Z","timestamp":1697706566000},"page":"627-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Automated AJCC Restaging for Oropharyngeal Cancer Research"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-9432","authenticated-orcid":false,"given":"Conrad W.","family":"Safranek","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah G.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rema","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-7987","authenticated-orcid":false,"given":"Saral","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"AJCC Cancer Staging Manual\u22128th Edition","author":"American Joint Committee on Cancer","year":"2017"},{"key":"e_1_2_7_3_1","volume-title":"AJCC Cancer Staging Manual\u22127th Edition","author":"American Joint Committee on Cancer","year":"2010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00603-7"},{"key":"e_1_2_7_5_1","unstructured":"About the National Cancer Database.ACS. Accessed June 7 2023.https:\/\/www.facs.org\/quality-programs\/cancer-programs\/national-cancer-database\/about\/"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:22:15Z","timestamp":1760970135000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ohn.558"],"URL":"https:\/\/doi.org\/10.1002\/ohn.558","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]},"assertion":[{"value":"2023-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}