{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:14:38Z","timestamp":1787800478873,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the characteristics of the time\u2010point distribution of the occurrence of hypopharyngeal\u2010proximal reflux episodes (HREs) in elderly and younger patients with laryngopharyngeal reflux (LPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Analysis of data from patients with LPR\u2010related symptoms and 24\u2011hour hypopharyngeal\u2010esophageal multichannel intraluminal impedance\u2010pH (24\u2010hour HEMII\u2011pH) monitoring from February 2017 to September 2022 at Sixth Medical Center of PLA General Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were divided into 2 age groups: the elderly group (&gt;60 years) and the younger group (\u226460 years). The time series of HREs and meals within 24\u00a0hours were analyzed based on HEMII\u2011pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 305 patients were included (126 elderly patients). In younger patients, except for nonacid\u2010gas HREs, the incidence of the remaining types of HREs tended to increase within 2\u00a0hours after meals, especially after dinner. The incidence of all types of HREs pre\u2010 and postmeal was not significantly different in the elderly group (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.080, <jats:italic>P<\/jats:italic>\u2009=\u2009.777). The incidence of nighttime HREs in elderly patients was statistically higher than in younger patients (6.23% vs\u00a03.96%, <jats:italic>P<\/jats:italic>\u2009=\u2009.030), particularly acid\u2010\/nonacid\u2010liquid HREs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HREs tend to increase within 2\u00a0hours after meals in younger LPR patients, except for nonacid\u2010gas HREs. In elderly LPR patients, the incidence of all types of HREs pre\u2010 and postmeal were not significantly different, and nighttime fluid HREs was more prone to occur than in younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.565","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:53:27Z","timestamp":1698047607000},"page":"845-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Time\u2011Point Distribution Characteristics of Laryngopharyngeal Reflux in Elderly Patients"],"prefix":"10.1002","volume":"170","author":[{"given":"Zhi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The Sixth Medical Center of PLA General Hospital of Beijing Beijing China"},{"name":"Department of Otolaryngology Navy Clinical College, The Fifth School of Clinical Medicine, Anhui Medical University Hefei Anhui 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