{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:25:22Z","timestamp":1776205522697,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of tobacco cessation following laryngeal cancer diagnosis on response to first\u2010line therapy, laryngectomy\u2010free survival, and overall survival in patients who were current smokers at the time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective, case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>OU Stephenson Cancer Center, National Cancer Institute\u2010Designated Cancer Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 140 patients diagnosed with laryngeal squamous cell carcinoma, who were current smokers at the time of diagnosis, and were treated with first\u2010line definitive radiation or chemo\/radiation with the intent to cure. The association between patient characteristics and treatment response was assessed using the <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test and logistic regression analysis. Survival outcomes were analyzed using Kaplan\u2010Meier methods and Cox proportional\u2010hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 140 current smokers, 61 patients (45%) quit smoking prior to treatment initiation. In adjusted logistic regression analysis, quitters had 3.7 times higher odds of achieving a complete response to first\u2010line therapy than active smokers (odds ratio: 3.694 [1.575\u20108.661]; <jats:italic>P<\/jats:italic>\u2009=\u2009.003). In the adjusted Cox proportional\u2010hazards model, quitters were 54% less likely to require salvage laryngectomy within 7 years of diagnosis than active smokers (hazard ratio: 0.456 [0.246\u20100.848]; <jats:italic>P<\/jats:italic>\u2009=\u2009.013). Quitters had a statistically significant increase in 7\u2010year overall survival compared to active smokers (<jats:italic>P<\/jats:italic>\u2009=\u2009.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to show that in newly diagnosed laryngeal cancer patients who are current smokers at the time of diagnosis, tobacco cessation significantly increases therapy response, laryngectomy\u2010free survival, and overall survival. These data stress the importance of systematically incorporating tobacco cessation programs into laryngeal cancer treatment plans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.567","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T15:15:18Z","timestamp":1698419718000},"page":"438-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tobacco Cessation Following Laryngeal Cancer Diagnosis Predicts Response to Treatment and Laryngectomy\u2010Free Survival"],"prefix":"10.1002","volume":"170","author":[{"given":"Matthew","family":"Krutz","sequence":"first","affiliation":[{"name":"Department\u00a0of Otolaryngology\u2013Head and Neck Surgery The University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department\u00a0of Biostatistics 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