{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:26:54Z","timestamp":1779100014070,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if perioperative ketorolac is associated with an increased rate of reoperation for hemorrhage after pediatric tonsillectomy at 30 days and 48\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single\u2010center retrospective propensity\u2010matched study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Quaternary pediatric hospital and ambulatory surgery center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients less than 18 years old undergoing tonsillectomy or adenotonsillectomy between January 1, 2015 and October 1, 2020 were included. Hemorrhage rates between exposed (K+) and unexposed (K\u2212) patients were calculated for the total cohort and a 1:1 propensity\u2010matched cohort. Additional analyses included: multivariable logistic regression, subgroup analysis of ASA 1 and 2 patients, subgroup analysis comparing children with teenagers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 5873 patients (42.1% K+) in the full cohort and 4694 patients in the propensity\u2010matched cohort. Reoperation for hemorrhage within 30 days occurred in 1.9% of K+ patients and 1.6% of K\u2212 patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.455) in the full cohort and 1.9% of K+ patients and 1.7% of K\u2212 patients (odds ratio [OR] 1.10, 95% confidence interval [CI] 0.72\u20101.69, <jats:italic>P<\/jats:italic>\u2009=\u20090.662) in the propensity\u2010matched cohort. Reoperation within 48\u2009hours occurred in 0.65% of K+ patients and 0.53% of K\u2212 patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.679) in the full cohort and 0.68% of K+ patients and 0.51% of K\u2212 patients (OR 1.33, 95% CI 0.63\u20102.81, <jats:italic>P<\/jats:italic>\u2009=\u20090.451) in the propensity\u2010matched cohort. There was no association between perioperative ketorolac administration and reoperation for hemorrhage in any of the other analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ketorolac at end of surgery should be considered as part of the nonopioid analgesic regimen for pediatric tonsillectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.577","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T04:29:46Z","timestamp":1699158586000},"page":"928-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Ketorolac on Reoperation for Hemorrhage After Pediatric Tonsillectomy: A Single\u2010Center Retrospective Propensity\u2010Matched Study"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-3034","authenticated-orcid":false,"given":"Rachel 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