{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:39:08Z","timestamp":1788244748568,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To develop and assess the validity of a novel allergy\u2010specific domain for the 22\u2010item sino\u2010nasal outcomes test (SNOT\u201022), to provide a new tool that efficiently quantifies the impact of allergic rhinitis (AR) concurrent with chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p><jats:italic>Prospective validation study<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:italic>Tertiary care hospital and community\u2010based clinic<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Proposed items were developed based on clinician and patient input, and further assessed via factor analysis and for internal consistency (<jats:italic>n<\/jats:italic>\u2009=\u20091987). Items were then additionally assessed for convergent and discriminant validity (<jats:italic>n<\/jats:italic>\u2009=\u2009415), applying data from concurrent completions of the Nasal Obstruction and Septoplasty Effectiveness Scale (NOSE), Mini\u2010Rhinoconjunctivitis Quality\u2010of\u2010Life Questionnaire (MiniRQLQ), and validated global health assessments. Assessments of intra\u2010rater reliability, responsiveness to change, and qualitative input were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Factor analysis demonstrated that proposed allergy items mapped to a single domain. Items were internally consistent (Cronbach <jats:italic>\u03b1<\/jats:italic>: 0.80 within domain,\u00a00.91 within all SNOT). In assessments of convergent validity, domain scores were associated with MiniRQLQ (Spearman's <jats:italic>\u03c1<\/jats:italic>: 0.46, 95% confidence interval [CI]: 0.30\u20100.59) and NOSE scores (0.36, 95% CI: 0.27\u20100.44). The novel items also discriminated among clinical states: a 1\u2010point increase in domain score was associated with an 8.32 (95% CI: 5.43\u201012.75) increase in the odds of prompting a visit for allergy\u2010related symptoms and a 1.52 (95% CI: 1.13\u20102.05) increase in the odds of positive allergy testing. Intra\u2010rater reliability was substantial (Cohen's <jats:italic>\u03ba<\/jats:italic>: 0.8, 95% CI: 0.8\u20100.9), and responsiveness to change was demonstrated (mean difference: \u22120.6, 95% CI: \u22120.8 to \u22120.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel domain is a valid, efficient measure of AR alongside rhinosinusitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.605","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T14:37:21Z","timestamp":1702478241000},"page":"937-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Validation of a Novel Allergy\u2010Specific Domain for the 22\u2010Item Sino\u2010Nasal Outcomes Test"],"prefix":"10.1002","volume":"170","author":[{"given":"Anne Y.","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers University Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carleton E.","family":"Corrales","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Willard","sequence":"additional","affiliation":[{"name":"Department of Surgery Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly A.","family":"Forrester","sequence":"additional","affiliation":[{"name":"Department of Surgery Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Washington University St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Surgery Brigham and Women's Hospital Boston 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