{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:51:31Z","timestamp":1790358691204,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the severity of the top 5 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) items ranked most important by patients with chronic rhinosinusitis with nasal polyps (CRSwNP), the effect of dupilumab on these items, and their association with objective disease measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Post hoc analysis of the SINUS\u201024 (NCT02912468) and SINUS\u201052 (NCT02898454) clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multinational, multicenter, randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients ranked the SNOT\u201022 items most affecting their health at baseline. Item symptom severity (0\u20105 scale) was assessed at baseline, Week 24 (W24), and Week 52 (W52). Changes in nasal polyps score (NPS) and Lund\u2013Mackay (LMK) scores were assessed in patients with\/without SNOT\u201022 items improvements of at least 1 severity group point at W24 and W52.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SNOT\u201022 items ranked most important at baseline were \u201cdecreased sense of smell\/taste\u201d (87% of patients), followed by \u201cnasal blockage\u201d (82%), \u201cpostnasal discharge\u201d (40%), \u201cthick nasal discharge\u201d (37%), and \u201cwake up at night\u201d (26%); 82%, 61%, 32%, 40%, and 26% of patients reported severe symptoms (score 4 or 5) for these items, respectively. Dupilumab improved score severity for all top 5 items versus placebo at W24 and W52. Improvements in NPS and LMK scores were numerically greater in patients with improvements in the SNOT\u201022 top 5 items.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Loss of smell\/taste was ranked as the most important symptom by patients with CRSwNP. Dupilumab reduced the severity of the top 5 most important SNOT\u201022 items versus placebo, in parallel with improvements in objective disease measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>SINUS\u201024 and SINUS\u201052 clinical trials were registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, identifiers NCT02912468 and NCT02898454, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.627","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T05:13:30Z","timestamp":1703826810000},"page":"1173-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of Dupilumab on Sinonasal Symptoms and Outcomes in Severe Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3993-1569","authenticated-orcid":false,"given":"Claire","family":"Hopkins","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-5007","authenticated-orcid":false,"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona, FRCB\u2010IDIBAPS Universitat de Barcelona, CIBERES Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-0116","authenticated-orcid":false,"given":"Asif H.","family":"Khan","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Sanofi Chilly\u2010Mazarin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-6606","authenticated-orcid":false,"given":"Stella E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Brigham and Women's Hospital Division of Otolaryngology\u2013Head &amp; Neck Surgery Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-0241","authenticated-orcid":false,"given":"Martin","family":"Wagenmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology D\u00fcsseldorf University Hospital (UKD) D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-688X","authenticated-orcid":false,"given":"Peter","family":"Hellings","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-229X","authenticated-orcid":false,"given":"Wytske","family":"Fokkens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-5855","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Msihid","sequence":"additional","affiliation":[{"name":"Health Economics and Value Assessment, Sanofi Gentilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-0149","authenticated-orcid":false,"given":"Radhika","family":"Nair","sequence":"additional","affiliation":[{"name":"Health Economics and Value Assessment, Sanofi Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-9184","authenticated-orcid":false,"given":"Siddhesh","family":"Kamat","sequence":"additional","affiliation":[{"name":"Medical Affairs Regeneron Pharmaceuticals Inc. 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