{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:30:50Z","timestamp":1773088250853,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the association between poor dental health and risk of oral cavity squamous cell cancer (OCSCC) at individual tumor subsites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control and cross\u2010sectional<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was performed using a population\u2010based cohort in North Carolina (Carolina Head and Neck Cancer Epidemiology Study [CHANCE]). A secondary cross\u2010sectional analysis was performed with an institutional cohort (WashU\/Siteman). Cases were adults with primary OCSCC and an identifiable tumor subsite. In the CHANCE cohort, controls were adults without head and neck cancer. In the Washington University\/Siteman cohort, patients with tongue cancer served as the comparator group. We used number of missing teeth (categorized 0\u20106, 7\u201024, 25\u201028) as a surrogate for poor dental health, which was self\u2010reported in CHANCE and measured on a pretreatment computed tomography scan in the WashU\/Siteman study. Adjusted odds ratios (aORs) for missing teeth were estimated for each tumor subsite using binomial logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Near complete tooth loss (25\u201028 teeth) was associated with a 3.5\u2010fold increased risk of alveolar ridge malignancy (aOR: 3.51; 95% confidence interval [CI]: 1.14\u201011.01, <jats:italic>P<\/jats:italic>\u2009=\u2009.03) in the CHANCE study. This association was confirmed in our cross\u2010sectional analysis (WashU\/Siteman study) where missing 25\u201028 teeth was associated with an increased risk of alveolar ridge compared to tongue cancer (aOR: 4.60; 95% CI: 1.97\u201011.10, <jats:italic>P<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests an association between poor dental health and risk of alveolar ridge cancer independent of smoking, alcohol use, age, race, and sex. Future prospective and translational studies are needed to confirm this association and elucidate the mechanism of dental disease in alveolar ridge malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.647","type":"journal-article","created":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T18:49:30Z","timestamp":1705258170000},"page":"1081-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Poor Dental Health as a Risk Factor for Alveolar Ridge Malignancies"],"prefix":"10.1002","volume":"170","author":[{"given":"Katherine W.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela L.","family":"Mazul","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington 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