{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:51:03Z","timestamp":1790020263556,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sarcopenia, characterized by decreased skeletal muscle mass, is associated with poorer oncologic outcomes in head and neck cancer (HNC) patients. The effect of sarcopenia on swallowing following HNC treatment is unknown. This study aims to investigate the association of sarcopenia and swallowing dysfunction in patients treated for HNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pretreatment sarcopenia was assessed using the skeletal muscle index\u00a0calculated from cross\u2010sectional imaging at the third cervical vertebra. Feeding tube dependence, patient\u2010reported dysphagia, and swallowing safety were assessed before and after treatment with the Functional Oral Intake Scale, Eating Assessment Tool\u201010, and Penetration Aspiration Scale, respectively. The association between sarcopenia and swallowing dysfunction was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 112 patients were included, 84 males (75%) and 28 females (25%). A total of 69 (61.6%) had sarcopenia prior to initiating HNC therapy. Sarcopenia was significantly associated with an elevated risk of patient\u2010reported dysphagia (odds ratio [OR]\u2009=\u20092.71\u00a0[95% confidence interval, CI, 1.12\u20106.79];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Multivariate logistic regression demonstrated that sarcopenia (OR\u2009=\u200915.18\u00a0[95% CI, 1.50\u2010453.53];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) is an independent predictor for aspiration following treatment for HNC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with pretreatment sarcopenia had higher rates of dysphagia before treatment and were more likely to develop aspiration after completion of HNC therapy. Sarcopenia is readily measured using cross\u2010sectional imaging and may be useful for identifying patients at risk of swallowing dysfunction and those most likely to benefit from prehabilitation efforts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.655","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:49:11Z","timestamp":1707274151000},"page":"1331-1337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Sarcopenia on Swallowing in Patients With Head and Neck Cancer"],"prefix":"10.1002","volume":"170","author":[{"given":"Angela A.","family":"Colback","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel V.","family":"Arkfeld","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Paydar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology University of California, Davis Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Raslan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology University of California, Davis Sacramento California 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