{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:53:49Z","timestamp":1789444429555,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association of social determinants of health (SDoH) in squamous cell carcinoma of the tongue in the United States and to evaluate the real\u2010world contribution of specific disparities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Centers for Disease Control and Prevention\u2010Social Vulnerability Index (SVI) and National Cancer Institute\u2010Surveillance, Epidemiology, and End Results Program\u00a0database were used to study 62,103 adult tongue squamous cell carcinoma patients from 1975 to 2017. Regression analysis assessed trends in months of follow\u2010up and survival across social vulnerability and 4 subcategories of social vulnerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As overall SVI score increases (increased social vulnerability), there is a significant decrease in the average length of follow\u2010up (22.95% decrease from 63.99 to 49.31 months;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) across patients from the lowest and highest social vulnerability groups. As overall SVI score increases, there is a significant decrease in the average months of survival (28.00% decrease from 49.20 to 35.43 months;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). There is also a significantly greater odds ratio (OR\u2009=\u20091.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) of advanced cancer staging upon presentation at higher SVI scores. Patients with higher SVI scores have a lower OR (0.93;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) of receiving surgery as their primary treatment when compared to patients with lower SVI scores. Patients with higher SVI scores also have a significantly greater OR (OR\u2009=\u20091.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) of receiving chemotherapy as their primary treatment when compared to patients with lower SVI scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased social vulnerability is shown to have a detrimental impact on the treatment and prognosis of patients with squamous cell carcinoma of the tongue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.675","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T07:29:22Z","timestamp":1707895762000},"page":"1338-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Influence of Social Vulnerability in Treatment and Prognosis of Squamous Cell Carcinoma of the Tongue"],"prefix":"10.1002","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-8274","authenticated-orcid":false,"given":"David J.","family":"Fei\u2010Zhang","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-463X","authenticated-orcid":false,"given":"Asher C.","family":"Park","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2378-2522","authenticated-orcid":false,"suffix":"Jr.","given":"Daniel C.","family":"Chelius","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Pediatric Thyroid Tumor Program and Pediatric Head and Neck Tumor Program, Baylor College of Medicine Texas Children's Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-0454","authenticated-orcid":false,"given":"Urjeet A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-3689","authenticated-orcid":false,"given":"Anthony M.","family":"Sheyn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology Le Bonheur Children's Hospital Memphis Tennessee USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Pediatric Otolaryngology St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Rastatter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology Ann &amp; Robert H. 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