{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:33:33Z","timestamp":1787067213359,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Temporal bone squamous cell carcinoma (TBSCC) is a rare malignancy with poor prognosis, and optimal treatment for advanced cases is uncertain. Our systematic literature review aimed to assess 5\u2010year survival outcomes for advanced TBSCC across different treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>EMBASE, Medline, PubMed, and Web of Science.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines for articles published between January 1989 and June 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The review yielded 1229 citations of which 31 provided 5\u2010year survival data for TBSCC. The final analysis included 1289 patients. T classification data was available for 1269 patients and overall stage for 1033 patients. Data for 5\u2010year overall survival (OS) was 59.6%. Five\u2010year OS was 81.9% for T1\/2 and 47.5% for T3\/4 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). OS for T1\/T2 cancers did not significantly differ between surgery and radiation (100% vs 81.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2009=\u2009.103). For advanced\u2010stage disease (T3\/T4), there was no statistical difference in OS when comparing surgery with postoperative chemoradiotherapy (CRT) (OS 50.0%) versus surgery with postoperative radiotherapy (XRT) (OS 53.3%) versus definitive CRT (OS 58.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2009=\u2009.767\u20101.000). There was not enough data to assess the role of neoadjuvant CRT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most patients will present with advanced\u2010stage disease, and nodal metastasis is seen in nearly 22% of patients. This study confirms the prognostic correlation of the current T classification system. Our results suggest that OS did not differ significantly between surgery and XRT for early stage disease, and combined treatment modalities yield similar 5\u2010year OS for advanced cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.678","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T04:09:56Z","timestamp":1707624596000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Survival Outcomes of Temporal Bone Squamous Cell Carcinoma: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-5327","authenticated-orcid":false,"given":"Krystelle","family":"Sioufi","sequence":"first","affiliation":[{"name":"Department of Family Medicine University of Montreal Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron 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