{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:20:47Z","timestamp":1767896447848,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Currently, the relationship between parathyroidectomy and objective neuropsychiatric outcomes are not clearly defined. The purpose of this study is to perform the first ever Meta\u2010analysis of preoperative and postoperative PHQ\u20109 and GAD\u20107 scores in patients with primary hyperparathyroidism undergoing parathyroidectomy with the goal of identifying a specific psychometric score that could be used as an indication for surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A comprehensive search of the literature was performed using PubMed, Embase, PsycINFO, Web of Science, and Ovid All EBM Reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Studies met inclusion criteria if they evaluated preoperative and postoperative PHQ\u20109 and\/or GAD\u20107 scores in patients with primary hyperparathyroidism undergoing parathyroidectomy. Random effects Meta\u2010analyses were used to analyze the compiled data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search returned 1433 articles for initial review of which 6 (1105 participants) met criteria for inclusion and Meta\u2010analysis. Meta\u2010analysis revealed that primary hyperparathyroidism patients had significantly higher presurgical PHQ\u20109 scores when compared to control groups. Additionally, patients experienced a statistically significant and sustained decrease in PHQ\u20109 scores following parathyroidectomy. Notably, there was a dramatic decrease in the percentage of patients with PHQ\u20109 scores \u226510 (considered clinically significant for depression) following parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with primary hyperparathyroidism experience a statistically significant and sustained improvement in PHQ\u20109 scores following parathyroidectomy. Additionally, symptoms of anxiety and suicidal ideation appear to decrease after parathyroidectomy. We propose that a PHQ\u20109 score \u226510 could potentially be used as an indication for parathyroidectomy in patients with asymptomatic primary hyperparathyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ohn.698","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T07:43:29Z","timestamp":1709106209000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["PHQ\u20109 and GAD\u20107 Score Response After Parathyroidectomy for Primary Hyperparathyroidism: a Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6698-1777","authenticated-orcid":false,"given":"John","family":"Caraway","sequence":"first","affiliation":[{"name":"F. 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Zimble Learning Resource Center Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8477-975X","authenticated-orcid":false,"given":"Michael","family":"Orestes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Walter Reed National Military Medical Center Bethesda Maryland USA"},{"name":"Department of Surgery Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196605262742105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.09.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2012.11.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2014.873702"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2022.04.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.4249"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4677"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-019-01830-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.12.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3715-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01447-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1476"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2010.03.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/16506073.2011.582138"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"e_1_2_8_22_1","unstructured":"CEBM (Centre for Evidence\u2010Based Medicine). 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