{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:44:24Z","timestamp":1790729064461,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Emerging evidence suggests a potential association between chronic rhinosinusitis (CRS) and obesity. With the increasing utilization of weight loss medications in the management of obesity, we aimed to assess the impact of glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101RA) prescription on the revision rate of functional endoscopic sinus surgery (FESS) and the use of biologics post\u2010FESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>US Collaborative Network within the TriNetX Analytics platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried the TriNetX Analytics platform for all adult CRS with nasal polyps (CRSwNP) patients with obesity who have undergone at least one prior FESS (based on Current Procedural Terminology [CPT] code). The incidence of revision surgery and first\u2010time biologic prescriptions (dupilumab, mepolizumab, and omalizumab) within a 1\u2010 and 5\u2010year follow\u2010up period was assessed, comparing those with and without GLP\u20101R agonist prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 1:1 propensity matching, there were a total of 1391 patients in each patient group. The GLP\u20101RA cohort had a significantly reduced incidence of revision FESS compared to the non\u2010GLP\u20101RA cohort at 1\u2010year (RR: 0.64; 95% CI: 0.41\u20100.98,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04) and 5\u2010year follow\u2010up periods (risk ratio [RR]: 0.60; 95% CI: 0.44\u20100.0.81,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001). At the 5\u2010year follow\u2010up, the first\u2010time biologic prescription was lower in the GLP\u20101RA cohort compared to the non\u2010GLP\u20101RA cohort (RR: 0.72; 95% CI: 0.52\u20100.98,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate that GLP\u20101RAs are associated with reduced postoperative revision FESS at up to a 5\u2010year follow\u2010up in CRSwNP patients. Future mechanistic and prospective studies are needed to confirm the association between GLP\u20101R agonists and improved post\u2010sinus surgery outcomes identified in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70072","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T16:58:51Z","timestamp":1765126731000},"page":"99-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing the Impact of GLP\u20101R Agonists in Post\u2010sinus Surgery Management"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-5291","authenticated-orcid":false,"given":"David","family":"Hoying","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Kaelber","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA"},{"name":"The Center for Clinical Informatics Research and Education The MetroHealth System Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad R.","family":"Chaaban","sequence":"additional","affiliation":[{"name":"Head and Neck Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"issue":"328","key":"e_1_2_9_2_1","first-page":"1","article-title":"National Ambulatory Medical Care Survey: 2000 summary","author":"Cherry DK","year":"2002","journal-title":"Adv Data"},{"key":"e_1_2_9_3_1","unstructured":"Adult obesity facts. Obesity. CDC. June 4 2024. Accessed August 3 2024.https:\/\/www.cdc.gov\/obesity\/php\/data-research\/adult-obesity-facts.html"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-023-00534-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.612"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07320-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.716"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-012-0495-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202004-0993OC"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13372"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105198"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1971973"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.05.030"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150134"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047230"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200903-013ST"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00053413"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214730"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcx125"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.043"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2021.102003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9155080"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:28:56Z","timestamp":1768404536000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ohn.70072"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70072","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]},"assertion":[{"value":"2025-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}