{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:31:53Z","timestamp":1786386713730,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to investigate predictive factors for residual disease in acquired cholesteatoma and determine whether the quality of the matrix having a continuous versus disrupted lining\u2014sac versus nonsac contained\u2014impacts the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pediatric and adult EAONO\u2010JOS\u2010staged acquired cholesteatoma operated with endoscopic and combined approaches by the senior author from January 2015 to November 2023 were included. Presence of residual disease was determined through second\u2010look surgery, MRI with DWI, or by clinical examination following canal wall down mastoidectomy. Initial occurrence of residual disease was examined relative to age, sac versus non\u2010sac contained matrix, ossicular status, and surgical approaches using Cox proportional hazard models. Kaplan\u2010Meier curves were used to visualize time to disease stratified by predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 105 ears included, 42% had residual disease. In isolation, non\u2010sac contained cholesteatoma (hazard ratio [HR] 3.89, 95% confidence interval [CI] 1.53\u20109.89), pediatric patients (HR 1.97, 95% CI 1.01\u20103.85), incus erosion (HR 2.43, 95% CI 1.17\u20105.05), and stapes erosion (HR 2.01, 95% CI 1.02\u20104.00) were significantly more likely to develop residual disease. EAONO\/JOS stage and surgical approach were not significantly related. In multivariable modeling, only matrix quality retained significance, with non\u2010sac contained matrix associated with a threefold higher hazard of residual disease (HR 3.05, 95% CI 1.17\u20107.93).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When accounting for several factors inherent to the disease process as well as surgical approach, a non\u2010sac contained cholesteatoma matrix was 3 times more likely to lead to residual disease in acquired cholesteatoma among all ages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70080","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T17:01:42Z","timestamp":1765126902000},"page":"503-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Non\u2010Sac Contained Matrix a Major Predictor for Residual Disease in Acquired Cholesteatoma?"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-3623","authenticated-orcid":false,"given":"Friederike S.","family":"Luetzenberg","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wald","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella A.","family":"Chrenka","sequence":"additional","affiliation":[{"name":"HealthPartners Institute, HealthPartners Bloomington Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-5284","authenticated-orcid":false,"given":"Manuela","family":"Fina","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Regions Hospital, HealthPartners St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30413"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)00126-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4396-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2024.241262"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.11.004"},{"issue":"5","key":"e_1_2_8_7_1","first-page":"550","article-title":"Predictive risk factors of residual cholesteatoma in children: a study of 256 cases","volume":"18","author":"Roger G","year":"1997","journal-title":"Am J Otol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.1422"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000948"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002823"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07400-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24633"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199106000-00006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2024.08.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.10.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2024.07.010"},{"issue":"3","key":"e_1_2_8_17_1","first-page":"153","article-title":"Results of endoscopic middle ear surgery for cholesteatoma treatment: a systematic review","volume":"34","author":"Presutti L","year":"2014","journal-title":"Acta otorhinolaryngologica Italica"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-suppl.1-43-2023-06"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12762"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2011.01.009"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480902963079"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2012.01.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2023.111641"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489417743519"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25591"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346140"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.12.008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13030836"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07996-w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2020.7598"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002168"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002549"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:26:24Z","timestamp":1786386384000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ohn.70080"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70080","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]},"assertion":[{"value":"2025-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}