{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:31:57Z","timestamp":1786386717298,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Procedures targeting the posterior nasal nerve (PNN) are effective in treating chronic rhinitis after failed medical therapy. We evaluate how ipratropium response predicts PNN intervention outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective review from January 2013 to June 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Setting<\/jats:title>\n                    <jats:p>Tertiary academic center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed patients with chronic rhinitis who trialed ipratropium nasal spray and received PNN surgical neurectomy or in\u2010office ablation (cryotherapy or radiofrequency ablation). Ipratropium responsiveness was self\u2010reported. Outcomes were assessed with the SNOT\u201022 questionnaire, focusing on rhinologic components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      81 patients (43 male, 38 female; mean age 57.9 years) were included, of whom 44 (54.3%) reported response to ipratropium. SNOT\u201022 rhinologic subdomain scores improved significantly following both in\u2010office PNN ablation (17.7\u2009\u00b1\u20095.8\u201014.5\u2009\u00b1\u20097.1,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04) and surgical neurectomy (19.1\u2009\u00b1\u20096.7\u201015.8\u2009\u00b1\u20097.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02). After PNN surgical neurectomy, ipratropium responders demonstrated significant improvement in postnasal drip (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03), nonresponders in rhinorrhea (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04), and both had similar rates of clinically meaningful improvement (MCID) in the SNOT\u201022 rhinologic subdomain (45.2% vs 50.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.73). In contrast, for in\u2010office PNN ablation, ipratropium responders had a significantly higher rate of MCID achievement (64.7% vs 27.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03) and significant improvements in rhinorrhea (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03), thick nasal discharge (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03), and rhinologic subdomain scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.03), while nonresponders had no significant symptom changes following in\u2010office ablation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with positive response to ipratropium may be more likely to benefit from PNN in\u2010office ablation techniques. Ipratropium response is not predictive of outcome for surgical PNN neurectomy, as both responders and nonresponders may experience benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70099","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:10:08Z","timestamp":1767186608000},"page":"359-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Value of Ipratropium Responsiveness on Posterior Nasal Nerve Neurectomy Outcomes in Chronic Rhinitis"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-273X","authenticated-orcid":false,"given":"Sainiteesh","family":"Maddineni","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University School of Medicine Palo Alto 94304 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University School of Medicine Palo Alto 94304 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel F.","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University School of Medicine Palo Alto 94304 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University School of Medicine Palo Alto 94304 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakar V.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University School of Medicine Palo Alto 94304 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-5880","authenticated-orcid":false,"given":"Michael T.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University School of Medicine Palo Alto 94304 California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"258","article-title":"Towards a new epidemiological definition of chronic rhinitis: prevalence of nasal complaints in the general population","volume":"59","author":"Avdeeva KS","year":"2021","journal-title":"Rhinol J"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13356"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0530"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924241247107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.268"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924221109987"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13991"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104553"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22574"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.033"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22028"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","unstructured":"SeaboldS PerktoldJ. 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