{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:32:02Z","timestamp":1786386722256,"version":"build-2736575974"},"reference-count":95,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To define survival and recurrence outcomes of HPV associated oropharyngeal squamous cell carcinoma (OPSCC) following transoral robotic surgery (TORS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Scopus, CINAHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were performed on studies employing TORS in HPV\u2010associated OPSCC. Meta\u2010analysis of continuous measures, proportions, and comparison of weighted proportion and relative risk were performed for patient characteristics and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 58 studies, comprising 16,129 adults treated with TORS for OPSCC, were included. The mean age was 59.5 years (SD 2.08) (range 18\u201093), with an average follow\u2010up of 43.4 months (SD 13.36); 83.5% of the cohort was male, and 85.6% had HPV\u2010positive OPSCC. In the HPV\u2010positive group, TORS survival rates were 91.0% at 1 year, 94.9% at 3 years, and 89.8% at 5 years. In comparison, the HPV\u2010negative group had survival rates of 92.3%, 84.2%, and 72.9%, respectively. Significant survival differences were observed between cohorts at 3 and 5 years (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). The HPV\u2010positive group had a significantly higher likelihood of 5\u2010year overall survival compared to the HPV\u2010negative group (RR\u2009=\u20091.18, 95% CI: 1.05\u20101.34) Recurrence rates in HPV\u2010positive patients were 2.0% local, 3.1% regional, and 5.3% locoregional, whereas HPV\u2010negative patients had recurrence rates of 7.6% local, 6.0% regional, and 9.1% locoregional (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0037, .2143, .426, respectively). Distant metastasis rates were 5.6% in HPV\u2010positive and 10.2% in HPV\u2010negative patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The higher survival rates and lower recurrences in HPV\u2010positive OPSCC patients compared to their HPV\u2010negative counterparts reflects the favorable long\u2010term oncologic outcome seen in HPV\u2010associated OPSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70101","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:19:16Z","timestamp":1768209556000},"page":"334-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oncologic Outcomes of Transoral Robotic Surgery in HPV\u2010Associated OPSCC: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"174","author":[{"given":"Matthew H.","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"},{"name":"SUNY Upstate Medical University, School of Medicine Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory Hyun\u2010su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA"},{"name":"Nova Southeastern University, College of Osteopathic Medicine Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-4571","authenticated-orcid":false,"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department 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