{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:02:13Z","timestamp":1786118533282,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate clinical features of unilateral sudden sensorineural hearing loss (SSNHL) in patients with autoimmune disease and identify factors influencing the prognosis of such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective, case\u2010control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A single tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with both unilateral SSNHL and autoimmune disease (n = 46) who were hospitalized between January 2018 and October 2023 were included in the autoimmune disease group. A control group propensity score matched for sex, age, and initial pure\u2010tone average (n = 183) comprised hospitalized patients with unilateral SSNHL but without autoimmune disease. The two groups were compared regarding clinical symptoms, audiological evaluations, vestibular function assessments, laboratory blood test results, and hearing outcomes. Prognostic factors were analyzed using binary logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Autoimmune disease and non\u2010autoimmune disease groups differed significantly in terms of the monocyte\u2010to\u2010lymphocyte ratio, total bilirubin, and indirect bilirubin (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) levels. Univariate analysis identified significant associations between hearing prognosis and the time from disease onset to treatment and final pure\u2010tone average, monocyte\u2010to\u2010lymphocyte ratio, indirect bilirubin, and high\u2010density lipoprotein levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Multivariate analysis further confirmed that time from disease onset to treatment and monocyte\u2010to\u2010lymphocyte ratio and indirect bilirubin levels were independent prognostic predictors in the autoimmune disease group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with unilateral SSNHL with autoimmune disease exhibited elevated levels of monocyte\u2010to\u2010lymphocyte ratio and reduced total bilirubin and indirect bilirubin levels as compared with those without autoimmune disease. Time from disease onset to treatment, monocyte\u2010to\u2010lymphocyte ratio, and indirect bilirubin levels were strongly associated with prognosis in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70104","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T20:04:27Z","timestamp":1767557067000},"page":"724-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Autoimmune Diseases on the Prognosis of Unilateral Sudden Sensorineural Hearing Loss"],"prefix":"10.1002","volume":"174","author":[{"given":"Yingjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujia","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-7338","authenticated-orcid":false,"given":"Mingming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"},{"name":"Department of Otology Medicine Shandong Provincial ENT Hospital Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62071-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104680"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/702807"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.06.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.4105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813506546"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01896-18"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397115666191016101741"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4333-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28455"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.223843"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859883"},{"key":"e_1_2_9_14_1","first-page":"443","article-title":"Guideline of diagnosis and treatment of sudden deafness (2015)","volume":"50","author":"Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association","year":"2015","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1586162"},{"issue":"3","key":"e_1_2_9_16_1","article-title":"Sensorineural hearing loss and systemic autoimmune disease: the experience of a systemic immune\u2010mediated diseases unit","volume":"13","author":"Ribeiro R","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26514"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.07.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00319-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(03)00006-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31268-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12780"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7691473"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519847860"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/01677063.2011.652266"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012492"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7165257"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002287"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000302"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.022"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23107"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0624-8"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70104","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:03:37Z","timestamp":1786032217000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ohn.70104"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70104","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"2025-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}