{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:54:17Z","timestamp":1787615657990,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The current gold standard for diagnosing eosinophilic chronic rhinosinusitis (ECRS) is tissue biopsy, but due to its invasive nature, there is a need for clinical diagnosis in outpatient settings or presurgical evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus up to July 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Compared the fractional exhaled nitric oxide (FeNO) levels between ECRS and non\u2010ECRS patients. The risk of bias across studies was evaluated utilizing the ROBINS\u2010I tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve studies comprising 1159 participants were included. The pooled mean difference in FeNO levels between ECRS and non\u2010ECRS patients was 32.21 ppb (95% CI: [19.36, 45.06],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The diagnostic odds ratio for FeNO in identifying ECRS was 8.78 (95% CI: [5.70, 13.51],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FeNO levels are significantly elevated in ECRS patients compared to non\u2010ECRS patients. The high diagnostic odds ratio suggests that FeNO has potential as a noninvasive diagnostic tool for ECRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70108","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:05:32Z","timestamp":1768208732000},"page":"593-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fractional Exhaled Nitric Oxide for Diagnosing Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-0859","authenticated-orcid":false,"given":"Jae Yoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine The Catholic University of Korea Seoul 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