{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:00:43Z","timestamp":1786118443690,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether earlier timing of cleft lip repair (CLR) is associated with differences in the incidence of hypertrophic scar (HTS) formation and the need for revision surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>TriNetX Analytics Network, a federated database of de\u2010identified health records from multiple healthcare institutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Infants who underwent primary CLR before 1 year of age were identified using ICD\u201010 and CPT codes. Patients were categorized into early cleft lip repair (ECLR, &lt;3 months) and traditional cleft lip repair (TLR, 3\u201012 months) groups. Propensity score matching was performed. Rates of HTS and revision surgery were compared between groups using chi\u2010squared tests and regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 6786 patients, 4321 underwent ECLR and 2465 underwent TLR. HTS was significantly less common in the ECLR group (3.2%) than in the TLR group (5.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002). Increasing age at repair was positively correlated with HTS incidence (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.58,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.048). However, revision surgery was more frequent following ECLR (6.6%) compared to TLR (2.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) with age inversely correlated to revision rate (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.52,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.104). These differences persisted after propensity score matching for demographic and clinical variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Earlier CLR (&lt;3 months) is associated with a lower rate of hypertrophic scarring but a higher rate of revision surgery. These findings underscore a trade\u2010off in timing decisions and may guide shared decision\u2010making for surgical planning in patients with cleft lip.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70133","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T08:44:03Z","timestamp":1769417043000},"page":"839-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimal Timing of Cleft Lip Repair: Correlation With Scar Formation and Revision Rates"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-8046","authenticated-orcid":false,"given":"Jamil","family":"Hayden","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals Cleveland Medical Center Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-5648","authenticated-orcid":false,"given":"Christopher L.","family":"Crafton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1879-8935","authenticated-orcid":false,"given":"Julia","family":"Keating","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-9950","authenticated-orcid":false,"given":"Ross","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7984-489X","authenticated-orcid":false,"given":"Howard","family":"Wang","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"Department of Plastic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-7512","authenticated-orcid":false,"given":"Cyrus","family":"Rabbani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals Cleveland Medical Center Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikrishna","family":"Gourishetti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University Hospitals Cleveland Medical Center Cleveland Ohio USA"},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_472_20"},{"key":"e_1_2_9_3_1","first-page":"223","article-title":"Complications of cleft lip surgery","volume":"3","author":"Wilhelmsen HR","year":"1966","journal-title":"Cleft Palate J"},{"key":"e_1_2_9_4_1","volume-title":"Cleft Craft: The Evolution of Its Surgery\u2014Volume I: The Unilateral Deformity","author":"Millard 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