{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:23:21Z","timestamp":1777987401084,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Currently, there is a lack of consensus regarding the superiority of specimen\u2010based versus tumor bed\u2010based intraoperative margin analysis in oral cavity squamous cell carcinoma (OCSCC). The purpose of this study is to perform the first meta\u2010analysis examining intraoperative margin assessment methods in OCSCC with the goal of determining if there is a significant difference in patient outcomes between specimen\u2010driven and tumor bed\u2010driven margin analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A comprehensive search of the literature was performed using PubMed, Embase, and Web of Science.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Studies met inclusion criteria if they conducted intraoperative specimen\u2010driven and tumor bed\u2010driven margin analysis in patients with OCSCC and reported patient outcomes. Random effects meta\u2010analyses were used to analyze the compiled data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The literature search returned 1988 articles for initial review of which 9 (1240 participants) met criteria for inclusion and meta\u2010analysis. Meta\u2010analysis revealed that a specimen\u2010based approach is associated with higher intraoperative re\u2010resection rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05), significantly lower final positive margin rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05), and decreased local recurrence when compared to the tumor bed\u2010based approach (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). However, there was no significant difference in overall recurrence when comparing intraoperative margin analysis methods (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05). Additionally, none of the included studies noted a significant difference in survival outcomes between tumor bed versus specimen\u2010based methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Specimen\u2010based frozen margin analysis in OCSCC results in lower false negative rates and improved local control; however, there is no significant difference in overall recurrence or survival when comparing specimen\u2010based vs tumor bed\u2010based techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70136","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:35:32Z","timestamp":1770384932000},"page":"881-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Margin Assessment Methods in Oral Cavity Squamous Cell Carcinoma: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6698-1777","authenticated-orcid":false,"given":"John","family":"Caraway","sequence":"first","affiliation":[{"name":"Department of Surgery Walter Reed National Military Medical Center Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Millay","sequence":"additional","affiliation":[{"name":"Department of Surgery Walter Reed National Military Medical Center Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Zarrella","sequence":"additional","affiliation":[{"name":"F. Edward H\u00e9bert School of Medicine Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"F. Edward H\u00e9bert School of Medicine Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Wrozek","sequence":"additional","affiliation":[{"name":"F. Edward H\u00e9bert School of Medicine Uniformed Services University of the Health Sciences Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery Walter Reed National Military Medical Center Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zamani","sequence":"additional","affiliation":[{"name":"Department of Research Programs Walter Reed National Military Medical Center Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-7192","authenticated-orcid":false,"given":"Nora","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Research Programs Walter Reed National Military Medical Center Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Heckman","sequence":"additional","affiliation":[{"name":"James A. 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