{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:23:59Z","timestamp":1777987439564,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To investigate practice patterns in the treatment of p16\u2010negative\/human papillomavirus (HPV)\u2010negative oropharyngeal squamous cell carcinoma (OPSCC) among members of the American Head and Neck Society (AHNS).<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Cross\u2010sectional.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Online electronic survey.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n An online survey was distributed via AHNS survey system. Participation was voluntary, and data were anonymously collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 108 members (7.7% of AHNS members) responded. Most (65.7%) had \u22655 years of experience in the field. Few practitioners (23.2% always and 10.2% frequently) confirmed HPV\u2010negative status with DNA\/RNA in situ hybridization or PCR testing for p16\u2010negative tumors. Most surgeons (60.2%) reported recommending TORS for identification of an unknown primary in a patient with p16\u2010\/HPV\u2010negative neck mass. Similarly, at least half (56.5%) of surgeons indicated always or frequently treating resectable T1\u2010T3 with TORS. The majority (73.2%) of surgeons indicated infrequently (59.3%) or never (13.9%) treating T3\/T4 with traditional open surgery as first line. More than half of the surgeons (57.4%) believed survival is better with surgery compared to definitive nonsurgical therapy for HPV\u2010negative OPSCC. There was wide variation in the use of treatment intensification (dual modality adjuvant treatment for T1\u20102N0, or tri\u2010modality treatment for T1\u2010T2N1), with 19.4% reporting never, 36.1% infrequently, 34.3% frequently, and 10.2% always doing so.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A majority of AHNS surgeons (57.4%) believe survival for HPV\u2010negative OPSCC is better with surgery. Most (56.5%) would treat resectable T1\u2010T3 tumors with TORS, while the minority (26.8%) would frequently or always operate on T3\u2010T4 tumors. There was wide variation in practice with respect to treatment intensifiication owing to remaining knowledge gaps in the field.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ohn.70150","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:05:31Z","timestamp":1769695531000},"page":"1018-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of P16\u2010Negative\/HPV\u2010Negative Oropharyngeal Squamous Cell Carcinoma: A Survey of AHNS Membership"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-1896","authenticated-orcid":false,"given":"Mustafa G.","family":"Bulbul","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West Virginia University Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University Health Network\/Princess Margaret Cancer Centre University of Toronto Toronto Canada"},{"name":"Institute for Health Policy, Management and Evaluation University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil D.","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-6168","authenticated-orcid":false,"given":"Meghan T.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West Virginia University Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814538605"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503163321104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20740"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02625"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5633"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820969613"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28617"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70471-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07654-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12287"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:37:20Z","timestamp":1777984640000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ohn.70150"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70150","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}