{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:22:52Z","timestamp":1777987372981,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To understand temporal trends in presentation and survival among patients with early\u2010onset oral cavity squamous cell carcinoma (EO\u2010OCSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Cancer Database (NCDB), 2004 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients younger than 50 years diagnosed with OCSCC in the NCDB. Annual case distributions by subsite, sex, and stage were modeled with logistic regression, reporting odds ratios (ORs) per calendar year over time. Kaplan\u2010Meier and Cox proportional hazards analyses assessed 5\u2010year overall survival (OS), stratified by age group, subsite, and stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 178,140 OCSCC cases, 21,630 (12.1%) were EO\u2010OCSCC with median age of 44 years. Tongue was the most common subsite (66.9%) and increased over time (OR\/year\u2009=\u20091.03; 95% CI, 1.02\u20101.04). Female cases rose steadily (OR\/year\u2009=\u20091.01; 95% CI, 1.01\u20101.02), narrowing the male\u2010female gap. Advanced\u2010stage disease increased by 5% annually in tongue tumors and 3% in non\u2010tongue tumors. Five\u2010year OS was higher in tongue (73.7%) than non\u2010tongue tumors (61.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and improved over time, with annual reductions in mortality risk of 1.1% for tongue and 1.9% for non\u2010tongue tumors. By age group, survival was highest for patients 20\u201029 years and lowest for those 40\u201049 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EO\u2010OCSCC is increasingly presenting as tongue primaries and in female patients, with a rising burden of advanced\u2010stage disease. Despite this unfavorable shift, survival has improved modestly across subsites, ages, and stages, underscoring the heterogeneity of EO\u2010OCSCC and the need for earlier detection and awareness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70151","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:24:12Z","timestamp":1769862252000},"page":"1025-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneity in Survival Over Time by Age, Sex, and Subsite in Early\u2010Onset Oral Cavity Cancer"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-7620","authenticated-orcid":false,"given":"Mateo","family":"Useche","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington School of Medicine Seattle Washington 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