{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:59:14Z","timestamp":1783000754673,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate trends in evaluation and management of patients with cCMV at a major pediatric center following the institution of universal cCMV screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary academic hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients &lt;18 years with a diagnosis of cCMV between January 2021 and February 2024 were examined. Three cohorts were analyzed: 2021 and earlier (before screening guidelines), 2022 (screening recommended but not mandated), and 2023 and later (universal screening). Patient charts were reviewed for workup and treatment of cCMV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      132 patients met criteria. There was a significant difference in age at first audiology visit following cCMV diagnosis between cohorts 1 (0.71\u2009\u00b1\u20091.8), 2 (0.26\u2009\u00b1\u20090.23), and 3 (0.07\u2009\u00b1\u20090.06) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02). There was a significant increase in the absolute number of mild hearing loss diagnoses in 2023 and later compared to 2022 (8 and 2,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01), but no difference in severe to profound hearing loss diagnoses between the cohorts (5 and 3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.2). Between cohorts 2 and 3, there were increases in the absolute number of patients undergoing ID consultation (11 vs 24), ENT consultation (9 vs 22), and treatment with antiviral therapy (7 vs 9) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Universal cCMV screening decreased the age at first audiology visit following cCMV diagnosis. Universal screening increased the number of diagnoses of mild hearing loss. The number of patients undergoing workup for cCMV also increased. Additional research is needed to assess the long\u2010term audiologic outcomes and benefits of universal screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70158","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:32:21Z","timestamp":1770384741000},"page":"997-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Mandated Universal Screening for Congenital Cytomegalovirus: The Minnesota Experience"],"prefix":"10.1002","volume":"174","author":[{"given":"Lily","family":"Holden","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa M.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asitha","family":"Jayawardena","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical School Minneapolis Minnesota USA"},{"name":"Department of Pediatric Otolaryngology\u2010Head and Neck Surgery Children's Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical School Minneapolis Minnesota USA"},{"name":"Department of Pediatric Otolaryngology\u2010Head and Neck Surgery Children's Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianne","family":"Roby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical School Minneapolis Minnesota USA"},{"name":"Department of Pediatric Otolaryngology\u2010Head and Neck Surgery Children's Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Lunos","sequence":"additional","affiliation":[{"name":"Department of Biostatisics. University of Minnesota, Biostatistical Design and Analysis Center, Clinical and Translational Science Institute Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2010Head and Neck Surgery Children's Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Rabusch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2010Head and Neck Surgery Children's Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-2508","authenticated-orcid":false,"given":"Andrew J.","family":"Redmann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Medical School Minneapolis Minnesota USA"},{"name":"Department of Pediatric Otolaryngology\u2010Head and Neck Surgery Children's Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13971-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/508173"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501319221106880"},{"key":"e_1_2_9_5_1","unstructured":"CMV in Newborns. CDC. January 17 2025. Accessed July 17 2025.https:\/\/www.cdc.gov\/cytomegalovirus\/congenital-infection\/index.html"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1790"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.2016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.113945"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2128"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.09.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404599"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.113934"},{"key":"e_1_2_9_14_1","unstructured":"The Vivian Act Legislation. MN Department of Health. December 19 2024. Accessed July 5 2025.https:\/\/www.health.state.mn.us\/diseases\/cytomegalovirus\/vivianact.html"},{"key":"e_1_2_9_15_1","first-page":"1","article-title":"Beyond hearing loss: exploring neurological and neurodevelopmental sequelae in asymptomatic congenital cytomegalovirus infection","volume":"8","author":"Swanson MR","year":"2025","journal-title":"Pediatr Res"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1332"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1079"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0354D"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70268-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2210"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80859-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.1229"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000001411"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01275.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit609"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0789"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.320"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110055"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000996"},{"key":"e_1_2_9_30_1","unstructured":"Reporting Cytomegalovirus (Congenital)\u2014MN Dept. of Health. Accessed September 11 2025.https:\/\/www.health.state.mn.us\/diseases\/cytomegalovirus\/report.html"},{"key":"e_1_2_9_31_1","unstructured":"Congenital Cytomegalovirus Surveillance\u2014MN Dept. of Health. Accessed September 11 2025.https:\/\/www.health.state.mn.us\/people\/newbornscreening\/program\/cmv\/surveillance.html"},{"key":"e_1_2_9_32_1","unstructured":"Tracking How Well cCMV Screening is Working. MN Department of Health. November 26 2024.https:\/\/www.health.state.mn.us\/about\/org\/phl\/annualreports\/2024\/ccmv.html"},{"key":"e_1_2_9_33_1","unstructured":"Minnesota is the First in the Nation to Screen all Newborns for cCMV. MN Department of Health. February 22 2024.https:\/\/www.health.state.mn.us\/about\/org\/phl\/annualreports\/2023\/ccmv.html"},{"key":"e_1_2_9_34_1","unstructured":"Congenital Cytomegalovirus Public Health Data\u2014MN Dept. of Health. Accessed September 11 2025.https:\/\/www.health.state.mn.us\/diseases\/cytomegalovirus\/congenital.html"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26490"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:36:51Z","timestamp":1777984611000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ohn.70158"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70158","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"2025-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}