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This study examines the impact of AR on CRSwNP, focusing on its links to tissue eosinophilic inflammation and postoperative recurrence risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on CRSwNP patients who underwent functional endoscopic sinus surgery. Based on the presence of comorbid AR, patients were categorized into AR and non\u2010AR groups. Baseline clinical data, peripheral and tissue eosinophil levels, and prognosis were analyzed. Multivariate Cox regression and Kaplan\u2010Meier survival analyses were used to assess associations with postoperative recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 603 patients with CRSwNP were included; 202 had comorbid AR. Compared with non\u2010AR patients, the AR group had higher rates of prior surgery and asthma and showed increased tissue eosinophil counts and percentages. During follow\u2010up, patients who recurred had a higher prevalence of AR, elevated peripheral and tissue eosinophil levels, more prior surgery, and higher Lund\u2010Mackay scores. Multivariable Cox regression and Kaplan\u2010Meier analysis identified AR as an independent predictor of postoperative recurrence. Moreover, a high tissue eosinophil burden independently associated with recurrence; within the recurrence cohort, AR patients exhibited significantly higher tissue eosinophil counts and percentages than non\u2010AR patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comorbid AR identifies a CRSwNP subgroup with marked tissue eosinophilia and increased risk of postoperative recurrence. It independently predicts earlier relapse and shorter recurrence\u2010free survival, likely by amplifying local eosinophilic inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70176","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:12:07Z","timestamp":1772957527000},"page":"1188-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Association Between Allergic Rhinitis, Eosinophilic Inflammation, and Postoperative Recurrence in Nasal Polyps"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3049-2013","authenticated-orcid":false,"given":"Wei","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Xiangya Hospital of Central South University Changsha People's Republic of China"},{"name":"Hunan Province Key Laboratory of Otolaryngology Critical Diseases 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