{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:31:15Z","timestamp":1784129475336,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271145"],"award-info":[{"award-number":["82271145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301283"],"award-info":[{"award-number":["82301283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101196\uff1a82101194"],"award-info":[{"award-number":["82101196\uff1a82101194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012430"],"award-info":[{"award-number":["2023A1515012430"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A03J0208"],"award-info":[{"award-number":["2023A03J0208"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the relationship between vitamin D (VD) levels and chronic rhinosinusitis (CRS), and to evaluate the therapeutic efficacy of VD supplementation for CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Two independent reviewers systematically searched PubMed, Embase, and the Cochrane Library to identify studies that assessed the association between CRS and VD, as well as the therapeutic effects of VD supplementation on CRS outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Meta\u2010analyses were conducted to compare VD levels between CRS patients and controls and to evaluate the efficacy of VD supplementation. Random\u2010 or fixed\u2010effects models were applied as appropriate. Sensitivity and subgroup analyses were performed to investigate potential sources of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A pooled analysis of 15 studies showed significantly lower serum VD levels in CRS patients compared to controls (SMD\u2009=\u2009\u20130.98;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Both 25(OH)D3 and 25(OH)D assays showed lower VD levels in CRS patients (SMD\u2009=\u2009\u20131.24,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001 vs SMD\u2009=\u2009\u20130.77,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Subgroup analyses also revealed consistent reductions in both CRS with nasal polyps (CRSwNP; SMD\u2009=\u2009\u20131.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and CRS without nasal polyps (CRSsNP; SMD\u2009=\u2009\u20131.02;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Moreover, four randomized controlled trials indicated that VD supplementation significantly improved Sino\u2010Nasal Outcome Test\u201022 (SNOT\u201022) scores at &lt;3 months (MD\u2009=\u2009\u20131.44;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001); however, this benefit was not maintained at \u22653 months (MD\u2009=\u2009\u20136.52;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CRS patients show significantly lower serum VD levels than healthy controls. VD supplementation may provide short\u2010term symptomatic improvement, although its long\u2010term efficacy remains unproven.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70182","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:08:23Z","timestamp":1773000503000},"page":"1135-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D Status and Supplementation in Chronic Rhinosinusitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8966-8487","authenticated-orcid":false,"given":"Shuyi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University No. 600 Tianhe Road, Tianhe District Guangzhou 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