{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:24:26Z","timestamp":1791606266016,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CRSwNP exhibits distinct inflammatory patterns across populations, with type 2 (T2) inflammation predominating in Western but less frequent in Asian patients. Recent single\u2010cell studies have highlighted fibroblast subsets contributing to T2 inflammation; however, the role of fibrocytes remains unclear. In this study, nasal polyp tissues from 10 adult patients meeting EPOS\/EUFOREA 2023 T2 criteria were analyzed using high\u2010parameter spectral flow cytometry (Sony ID7000) to assess IL\u20104, IL\u20105, and IL\u201013 expression across epithelial and immune cell types. Fibrocytes demonstrated the highest IL\u20104 and IL\u201013 expression, comparable to T cells, whereas IL\u20105 expression showed no significant difference among cell types. These findings suggest that fibrocytes may be a previously underrecognized T2 cytokine\u2010producing population in CRSwNP, and that fibrocytes, together with T cells, may be key drivers of type 2 inflammation and represent potential therapeutic targets in Asian patients with CRSwNP.<\/jats:p>","DOI":"10.1002\/ohn.70197","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:08:07Z","timestamp":1774181287000},"page":"1372-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fibrocytes as Key Mediators of Type 2 Inflammation in Asian Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-1421","authenticated-orcid":false,"given":"Steven Chun\u2010Kang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital Yunlin Branch Yunlin 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