{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:43Z","timestamp":1788797563949,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271165"],"award-info":[{"award-number":["82271165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2022548"],"award-info":[{"award-number":["A2022548"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202201011589"],"award-info":[{"award-number":["202201011589"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate brain network reorganization in tinnitus patients undergoing tailor\u2010made notched music training (TMNMT) or tinnitus retraining therapy (TRT) and assess whether baseline network characteristics predict treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A randomized, single\u2010blind, controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was conducted at Sun Yat\u2010sen Memorial Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged 18 to 70 years with tinnitus lasting more than 6 months were randomly assigned to receive either TMNMT or TRT for 3 months. Electroencephalogram (EEG) assessed brain functional and effective connectivity at baseline and after treatment. Additionally, 46 normal controls with a single EEG scan were included for baseline comparison to assess treatment normalization of brain networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 80 patients (TMNMT group: 40 [50.0%]; mean [SD] age: 42.2 [12.0] years; 19 males [47.5%]; TRT group: 40 [50.0%]; mean [SD] age: 41.9 [14.6] years; 21 males [52.5%]) and 46 normal controls (mean [SD] age: 39.37 [12.92] years; 23 males [50.0%]) were analyzed. In tinnitus patients who responded to TMNMT or TRT, tinnitus severity reduction was associated with reorganization of multiple brain networks. Predictive analysis showed that increased effective connectivity from the posterior cingulate cortex and insula to the auditory network predicted TMNMT responders (area under the curve [AUC]\u2009=\u20090.820, 95% CI 0.697\u20100.944), while increased connectivity from the medial prefrontal cortex to the dorsolateral prefrontal cortex predicted TRT non\u2010responders (AUC\u2009=\u20090.875, 95% CI 0.777\u20100.974).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both TMNMT and TRT induced neural effects on tinnitus. Baseline brain networks distinguished responders from non\u2010responders and predicted treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70210","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:16:00Z","timestamp":1774181760000},"page":"1583-1592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Individual\u2010Level Brain Network Predictors and Distinct Reorganization Mechanism in Sound Therapies for Tinnitus"],"prefix":"10.1002","volume":"174","author":[{"given":"Jiahong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou City Guangdong Province China"},{"name":"Institute of Hearing and Speech\u2010Language Science Sun Yat\u2010sen University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaopeng","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou City Guangdong Province China"},{"name":"Institute of Hearing and Speech\u2010Language Science Sun Yat\u2010sen University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou City Guangdong Province China"},{"name":"Institute of Hearing and Speech\u2010Language Science Sun Yat\u2010sen University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou City Guangdong Province China"},{"name":"Institute of Hearing and Speech\u2010Language Science Sun Yat\u2010sen University Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Center for Hearing and Balance Zhuhai Hospital of Integrated of Traditional Chinese Medicine and Western Medicine Zhuhai Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou City Guangdong 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