{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:41Z","timestamp":1788797561316,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although short\u2010term health\u2010related quality of life (HRQoL) outcomes in survivors of oropharyngeal squamous cell carcinoma (OPSCC) are well characterized, long\u2010term HRQoL outcomes (\u22655 years posttreatment) are not well established. This systematic review aims to assess long\u2010term HRQoL in OPSCC survivors and identify potential predictors influencing these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A comprehensive search of the literature was performed using PubMed, Embase, Web of Science, and Ovid All EBM Reviews (Cochrane).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Studies met inclusion criteria if they were in English, included OPSCC patients \u22655 years posttreatment, and reported OPSCC\u2010specific HRQoL outcomes measured by validated questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature search returned 2656 articles for initial review, of which 7 (771 participants, range 9\u2010396) met inclusion criteria. Heterogeneous reporting and lack of raw data precluded meta\u2010analysis. Across validated instruments, survivors demonstrated persistent dysphagia, xerostomia, and diet restriction; however, global HRQoL was generally preserved. Subgroup analyses indicated that single\u2010modality treatment and p16 positivity were associated with better long\u2010term QoL, while advanced stage, base of tongue primary site, chemotherapy use, PEG\u2010tube dependence, smoking or alcohol use at diagnosis, older age, and lower educational attainment predicted poorer QoL outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term OPSCC survivors experience persistent functional impairments despite generally preserved global HRQoL. Standardized, longitudinal studies are needed to better characterize predictors of long\u2010term HRQoL and inform targeted survivorship interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70219","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:35:46Z","timestamp":1774564546000},"page":"1421-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Health\u2010Related Quality of Life in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2043-1067","authenticated-orcid":false,"given":"Dominique","family":"Zarrella","sequence":"first","affiliation":[{"name":"F. 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