{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:35Z","timestamp":1788797555902,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the prognostic significance of the margin\u2010to\u2010depth of invasion ratio (MDR) in pathological nodal negative (pN0) oral tongue squamous cell carcinoma (OTSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Case series with chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with pN0 OTSCC who underwent primary radical surgery and high\u2010quality neck dissection (lymph node yield \u226518) without positive margin (&lt;1\u2009mm) between 2007 and 2017 were retrospectively analyzed. Cox proportional hazards models were utilized to identify factors associated with survival outcomes, including cancer\u2010specific survival (CSS) and relapse\u2010free survival (RFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 296 patients were enrolled in this study. The optimal cutoff value for MDR was determined to be 0.29. For those with high MDR, the 5\u2010year CSS and RFS were significantly superior compared to those with low MDR (CSS: 92.8% vs 71.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001; RFS: 89.3% vs 67.9%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). In the multivariate Cox model, a low MDR remained an independent negative prognosticator of CSS (HR: 2.846, 95% CI: 1.229\u20106.593,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.015) and RFS (HR: 2.661, 95% CI: 1.126\u20106.288,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.026). In radical surgery without adjuvant therapy subgroup patients, patients with a low MDR had significantly poorer CSS and RFS than patients with a high MDR (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among pN0 OTSCC patients with negative surgical margins (\u22651\u2009mm), survival outcomes differed significantly between the high and low MDR groups. Patients with a low MDR had a markedly higher risk of recurrence and poorer cancer\u2010specific survival, suggesting that adjuvant treatment may be warranted for this subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70222","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:10:49Z","timestamp":1774883449000},"page":"1524-1532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Margin to Depth of Invasion Ratio on Oncologic Outcomes in Node\u2010Negative Oral Tongue Cancer"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-948X","authenticated-orcid":false,"given":"Kai\u2010Shan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tsai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yen","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"Doctoral Program of Clinical and Experimental Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Min","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"},{"name":"Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-1686","authenticated-orcid":false,"given":"Chao\u2010Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lu","sequence":"additional","affiliation":[{"name":"Doctoral Program of Clinical and Experimental Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-1579","authenticated-orcid":false,"given":"Ming\u2010Hsien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010sen University Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University Taoyuan 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