{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:41:41Z","timestamp":1788914501577,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study used a systematic review and meta\u2010analysis to evaluate the tolerance and rate of postoperative complications associated with using granules of S53P4 bioactive glass (BAG) for mastoid obliteration surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in PubMed\/MEDLINE, Scopus, Web of Science, and the Cochrane Library.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis was performed according to the PRISMA statement. Data from eligible studies were extracted and used to calculate the pooled rate of postoperative complications and pooled audiologic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12 studies (583 patients; 54.1% males; median age 41.6 years) was included. The mean follow\u2010up was 28.8 months (95% CI: 18.5\u201039.1). We found a pooled complication rate of 16% of patients (n\u2009=\u2009542; 95% CI: 0.11\u20100.22) for postoperative transient or persistent otorrhea, 2% (n\u2009=\u2009529; 95% CI: 0.01\u20100.05) for surgical wound infection and 1% (n\u2009=\u2009570; 95% CI: 0.01\u20100.03) for extrusion of BAG granules into the external auditory canal. The pooled rate was 6% (n\u2009=\u2009239, 95% CI: 0.01\u20100.30) for Merchant grade 2 or 3 at last follow\u2010up, indicating persistent or uncontrolled otorrhea. Pooled audiologic outcomes revealed that bone conduction remained stable between the preoperative and postoperative setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>S53P4 BAG granules seem a safe material for mastoid obliteration, with a low rate of postoperative complications and good inner\u2010ear tolerance. Further multicenter prospective studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70228","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:17:17Z","timestamp":1775481437000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mastoid Obliteration Using Granules of S53p4 Bioactive Glass: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9957-149X","authenticated-orcid":false,"given":"Luca","family":"Canali","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"},{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele Milan Italy"},{"name":"Otorhinolaryngology, Head and Neck department IRCCS Humanitas Clinical and Research Center, Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-7187","authenticated-orcid":false,"given":"Matteo","family":"Di Bari","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Ospedale Nuovo di Legnano, ASST Ovest Milanese Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6427-3102","authenticated-orcid":false,"given":"Sean C.","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5928-1511","authenticated-orcid":false,"given":"Lauranne","family":"Alciato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-3104","authenticated-orcid":false,"given":"Olivier","family":"Sterkers","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8816-0883","authenticated-orcid":false,"given":"Hugo","family":"Delille","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-8847","authenticated-orcid":false,"given":"Daniele","family":"Bernardeschi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re AP\u2010HP, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749690609500204"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/684826"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199807)20:4<315::AID-HED6>3.0.CO;2-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941011900603"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000854"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2021.01.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30413"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06120-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3143-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003057"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_13_1","unstructured":"National Institute for Health and Care ExcellenceMethods for the Development of NICE Public Health Guidance. National Institute for Health and Care Excellence (NICE);2012. Accessed July 1 2024.http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK395862\/"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4040"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1482"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3102\/10769986030003261"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.923"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12748"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07850-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003685"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2021.9053"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121001195"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07262-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100901"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02472-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812438168"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103601"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.03.007"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-191112000-00007"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31825f2346"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000282"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2393-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2024.241262"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08297-y"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2019.7038"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70273-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200401000-00004"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.3401"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70228","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:05:52Z","timestamp":1783015552000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ohn.70228"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70228","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}