{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:44Z","timestamp":1788797564025,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are approved to treat obstructive sleep apnea (OSA), yet their use in an OSA population has not been characterized. This study evaluates GLP\u20101 RA use in patients presenting to a sleep surgery clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary care institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with OSA who presented to our sleep surgery clinic between October 2023 and March 2025 with available sleep studies were included (n\u2009=\u2009384). Demographic data, body mass index (BMI), apnea\u2010hypopnea index (AHI), OSA history, GLP\u20101 RA prescription data, and usage details were collected through chart review. Eligibility for GLP\u20101 RA was defined by FDA drug labeling criteria, with diabetes, obesity, or BMI\u2009\u2265\u200927\u2009kg\/m\u00b2 with a weight\u2010related comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort had mean age 53.3\u2009\u00b1\u200914.8 years, BMI 29.4\u2009\u00b1\u20095.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and AHI 28.7\u2009\u00b1\u200924.2\u2009events\/h. Most patients (52.1%) had tried CPAP. Among the full cohort (n\u2009=\u2009384), 249 patients (64.8%) met FDA\u2010approved drug labeling criteria for GLP\u20101 RA use, and there were 70 (28.1%) current GLP\u20101 RA users among eligible patients. Semaglutide (54.8%) and tirzepatide (27.4%) were the most prescribed. The most common reasons for discontinuing or changing GLP\u20101 RA types were insurance\u2010related issues and adverse effects. Among eligible patients, having Medicaid was associated with lower likelihood of using GLP\u20101 RAs (adjusted odds ratio 0.25,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.04) while BMI\u2009\u226530\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (adjusted odds ratio 3.45,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) was associated with higher likelihood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among sleep surgery clinic patients, a large proportion were eligible for GLP\u20101 RA use, and utilization was high compared to that of the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70231","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:09:08Z","timestamp":1776172148000},"page":"1633-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Glucagon\u2010Like Peptide\u20101 Receptor Agonist Utilization Among Sleep Surgery Clinic Patients"],"prefix":"10.1002","volume":"174","author":[{"given":"Rachel B.","family":"Kutler","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons NewYork\u2010Presbyterian\/Columbia University Irving Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons NewYork\u2010Presbyterian\/Columbia University Irving Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons NewYork\u2010Presbyterian\/Columbia University Irving Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Trackey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons NewYork\u2010Presbyterian\/Columbia University Irving Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rivera\u2010Diaz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons NewYork\u2010Presbyterian\/Columbia University Irving Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Jelic","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine Columbia University Irving Medical Center New York New York USA"},{"name":"Center of Excellence for Sleep &amp; 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