{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:27:51Z","timestamp":1783020471037,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study compares recurrence patterns after subtotal resection (STR) of neurofibromatosis type 2 (NF\u20102)\u2010associated versus sporadic vestibular schwannomas (VSs) and aims to identify independent predictors of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective matched\u2010cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single tertiary academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified patients who underwent STR for VS between 2004 and 2024. A cohort of 21 NF\u20102 patients was matched to 79 sporadic controls based on age, sex, and tumor size (Koos grade). Preoperative and postoperative tumor volumes were calculated and included as covariates in survival analyses. The primary outcome was recurrence\u2010free survival, analyzed using Kaplan\u2010Meier methods and Cox proportional hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NF\u20102 cohort experienced a higher overall recurrence rate than the matched sporadic cohort (42.9% vs 16.5%). In a multivariable Cox regression model adjusting for clinical and volumetric covariates, NF\u20102 status emerged as a strong, significant independent predictor of recurrence (adjusted hazard ratio [aHR] 4.83; 95% CI 1.25\u201018.62;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.022). This association was absent in the full, unmatched cohort, highlighting the importance of the matched design. No other variables, including postoperative adjuvant radiation, were significant predictors in the final matched model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this matched\u2010cohort analysis, the intrinsic biology of germline\n                      <jats:italic>NF2<\/jats:italic>\n                      is a powerful, independent driver of tumor recurrence following STR. This finding, unmasked by controlling for key confounders, suggests that the elevated recurrence risk in NF\u20102 patients is a direct consequence of the underlying genetic disorder. These results underscore the distinct natural history of NF\u20102\u2010associated tumors and support the need for lifelong surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70242","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:14:42Z","timestamp":1776172482000},"page":"181-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrence After Subtotal Resection of NF\u20102\u2010Associated Versus Sporadic Vestibular Schwannomas: A Matched\u2010Cohort Analysis"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5253-6392","authenticated-orcid":false,"given":"Stephanie","family":"Younan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Chang\u2010Chien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithvik","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Al\u2010Adli","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Limb","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Sharon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew Song","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Theodosopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin A.","family":"Morshed","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-5065","authenticated-orcid":false,"given":"Nicole T.","family":"Jiam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2010San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01155-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60259-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2020394"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz153"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.12.FOCUS17669"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.FOCUS12163"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115850"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.04.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1776124"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2022.05.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.32080"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101498"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.12.JNS151857"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301395"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.817071"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.01.019"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000003215"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1335605"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.125"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-523-7_10"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181d2777f"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199701000-00001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14184429"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf7295"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076522"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28998"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400985"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-025-06522-7"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:04:38Z","timestamp":1783015478000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ohn.70242"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70242","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}