{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:06:53Z","timestamp":1790878013488,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of irreversible electroporation for non\u2010thermal ablation of tonsils in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective interventional case series of 24 adult patients referred for tonsillectomy that were followed for 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The procedures were performed under general anesthesia or sedation. Irreversible electroporation was applied to the tonsils using the ENTire\n                      <jats:sup>TM<\/jats:sup>\n                      system. Pain was assessed daily using a pain scale for the first postoperative week. Tonsil sizes were assessed at baseline and 1 and 3 months postoperatively. The Tonsil and Adenoid Health Status Instrument and the Snore\u2010Visual Analog Scale (VAS) questionnaires were administered at baseline and at 3 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 23 adult patients (mean age: 36.5\u2009\u00b1\u200914.0; mean body mass index [BMI]: 25.5\u2009\u00b1\u20094.1) completed the study. No bleeding was observed intra\u2010 or postoperatively. Procedural time was 7.98\u2009\u00b1\u20092.62\u2009minutes. A pain scale score below 2 was reported 4.5\u2009\u00b1\u20091.7 days after intervention. Reduction in tonsillar size was observed from 2.4\u2009\u00b1\u20090.9 pre\u2010intervention to 1.3\u2009\u00b1\u20091.0 at 3 months post\u2010intervention (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Tonsil and Adenoid Health Status scores decreased from 17.7\u2009\u00b1\u200913.0 to 0.96\u2009\u00b1\u20091.7 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The Snore\u2010 VAS score decreased by 72%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first clinical study to investigate the use of irreversible electroporation for tonsillar ablation. Irreversible electroporation shows promise as a minimally invasive procedure for reducing the size of tonsillar hypertrophy and alleviating symptoms, with negligible bleeding and significantly less pain. Multicenter studies are in progress to evaluate long\u2010term efficacy including in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70276","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:49:21Z","timestamp":1777538961000},"page":"373-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Irreversible Electroporation for Tonsillar Ablation in Adults"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-7772","authenticated-orcid":false,"given":"Codrut","family":"Sarafoleanu","sequence":"first","affiliation":[{"name":"Department of ORL&amp;HNS Sfanta Maria Hospital University of Medicine Carol Davila Bucharest 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