{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:04:04Z","timestamp":1785344644523,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001828","name":"Erasmus Universiteit Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003061","name":"Erasmus Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between distortion product otoacoustic emission (DPOAE) signal\u2010to\u2010noise ratios (SNRs) and pure\u2010tone audiometry (PTA) thresholds in adolescents, both cross\u2010sectionally at age 18 and longitudinally by evaluating whether DPOAE SNRs at age 13 predict high\u2010frequency hearing loss (HFHL) at age 18.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The Generation R Study, a population\u2010based birth cohort in Rotterdam, the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PTA thresholds and DPOAEs were obtained at ages 13 (April 2016 to September 2019) and 18 (October 2020 to May 2024). Participants with abnormal middle ear function, based on tympanometry, were excluded. HFHL was defined as PTA thresholds \u2264\u200915\u2009dB HL at 500 and 1000\u2009Hz and &gt;15\u2009dB HL averaged across 3, 4, 6, and 8\u2009kHz. Receiver operating characteristic (ROC) curves were used to evaluate the ability of DPOAE SNRs to distinguish between HFHL and normal hearing. Sensitivity and specificity were calculated for different SNR thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis of 3463 ears at age 18 showed that DPOAE SNRs discriminated between ears with and without HFHL, yielding an area under the curve (AUC) of 0.830. Longitudinally, SNR values at age 13 predicted HFHL at age 18, with an AUC of 0.743.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DPOAE SNRs demonstrate good accuracy for detecting HFHL in adolescents and moderate accuracy for predicting future HFHL. These findings support the potential role of DPOAEs as a noninvasive screening tool to enable early detection of high\u2010frequency cochlear dysfunction suggestive of early\u2010stage noise\u2010related hearing damage in youth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70284","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:44:41Z","timestamp":1779277481000},"page":"480-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Evaluation of Otoacoustic Emissions as a Screening Tool for High\u2010Frequency Hearing Loss in Adolescents"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3076-5015","authenticated-orcid":false,"given":"Stefanie N. H.","family":"Reijers","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline E.","family":"Meerkerk\u2010Meijer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jantien L.","family":"Vroegop","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Geleijnse","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"van der Schroeff","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.382104"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-6911-7_9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1463-1741.195798"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/nah.nah_38_21"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2003.009209"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AUD.0000090439.16438.9F"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.413320"},{"key":"e_1_2_8_9_1","unstructured":"RamosJA.An overview of OAEs and normative data for DPOAEs: a review of OAE concepts the application of screening versus diagnostic OAEs as well as normative data to help clinicians in the interpretation of DPOAEs for the Interacoustics Titan DPOAE440 module.Hear Rev.2013;20(11):30+.https:\/\/link.gale.com\/apps\/doc\/A349000118\/AONE?u=erasmus&sid=bookmark-AONE&xid=66e149bd"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2204437"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a035493"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1432979"},{"key":"e_1_2_8_13_1","unstructured":"Deafness and hearing loss. 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