{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:03:44Z","timestamp":1785344624719,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1K08CA293255-0"],"award-info":[{"award-number":["1K08CA293255-0"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate patient priorities that may inform the choice of laryngeal cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Multi\u2010institutional, survey\u2010based, conjoint analysis study focusing on seven attributes: lifespan, treatment type, cancer cure, self\u2010image, mode of breathing, voicing, and swallowing. Patients with a history of treated laryngeal cancer (&gt;6 months from treatment completion with no evidence of recurrent disease) were recruited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary care medical centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Conjoint analysis yields utility scores, a quantitative measure of preference for an attribute. Higher utility scores indicate greater preference. Chi\u2010squared, univariate logistic regression, and univariate linear regression analyses were used to evaluate associations between patient demographic and medical features with relative attribute preference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 151 patients with previously treated laryngeal cancer. For the cohort, the mean importance scores (\u00b1standard deviation) were swallowing 25.7% (\u00b18.4%), lifespan 21.5% (\u00b19.3%), cancer cure 14.0% (\u00b16.4%), mode of breathing 12.8% (\u00b14.8%), voicing 9.2% (\u00b13.5%), treatment type 9.1% (\u00b15.0%), and self\u2010image 7.7% (\u00b14.4%). Patients who required salvage surgery after upfront chemoradiotherapy placed more value on cancer cure compared to the other treatment groups (coefficient 2.76, 95% CI 0.33\u20105.19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with a history of treated laryngeal cancer, swallowing is the most important treatment priority, followed closely by lifespan. However, patients who underwent salvage surgery placed more value on cancer cure during decision\u2010making. These findings demonstrate that patient treatment preferences are diverse and may change throughout the cancer care journey, with some patients placing a higher value on quality of life than lifespan and cancer cure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70286","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:14:12Z","timestamp":1781709252000},"page":"409-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Priorities in Patients With a History of Laryngeal Cancer: A Conjoint Analysis"],"prefix":"10.1002","volume":"175","author":[{"given":"Montana K.","family":"Upton","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhura","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis Miller","family":"Dennison","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery at Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Kondapaneni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Abemayor","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abie H.","family":"Mendelsohn","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sinard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tassone","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Missouri Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Topf","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4639-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29241"},{"key":"e_1_2_9_5_1","unstructured":"Cancer of the glottic larynx (version 1.2023). 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