{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:15:58Z","timestamp":1788030958989,"version":"build-2784847793"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether extending the dupilumab dosing interval beyond the standard every\u2010two\u2010weeks (Q2W) regimen maintains clinical, radiologic, and biomarker control in adults with chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Scopus, Cochrane Library, and Web of Science were systematically searched using predefined terms related to CRSwNP and dupilumab, with the final search in September 2025. Reference lists of included studies were also screened.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Eligible studies enrolled adults with CRSwNP who transitioned from dupilumab 300\u2009mg Q2W to extended intervals (\u2265Q4W). Two reviewers independently screened, extracted data, and assessed risk of bias using RoB2 and NIH tools. Random\u2010effects meta\u2010analyses synthesized sinonasal, radiologic, and biomarker outcomes. Subgroup analysis also compared switching after 6 versus 12 months of standard\u2010dosing induction period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen studies met the inclusion criteria, and nine contributed to quantitative synthesis. Across 1075 patients, extended interval dosing preserved disease control. Pooled mean differences (Q4W vs Q2W) showed non\u2010significant changes in 22\u2010item Sinonasal Outcome Test (SNOT\u201022) (\u22120.56), nasal congestion (\u22120.73), olfaction (+0.23), nasal polyp score (\u22120.29), and Lund\u2010Mackay score (\u22121.25). Eosinophils decreased significantly (\u22120.13\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.047). Subgroup analysis revealed a non\u2010significant difference in clinical outcomes of Q4W dosing when comparing the 12\u2010 and 6\u2010month induction protocols. Real\u2010world studies showed the feasibility of further extension (Q6W\u2010Q12W) in selected patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dupilumab interval extension to Q4W maintains clinical stability after 6 to 12 months of standard dosing, with potential for longer intervals in selected patients. Further controlled trials are required to define optimal tapering strategies and identify predictors of successful dose spacing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70295","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:59:41Z","timestamp":1781521181000},"page":"527-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dupilumab Extended Interval Dosing in Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-4972","authenticated-orcid":false,"given":"Abdulsalam","family":"Alqutub","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Makkah Health Cluster Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr I.","family":"Herzallah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulafa","family":"Alqutub","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine University of Jeddah Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Assiri","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery King Faisal Medical Complex Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2973-1061","authenticated-orcid":false,"given":"Islam R.","family":"Herzallah","sequence":"additional","affiliation":[{"name":"Rhinology &amp; Endoscopic Skull Base Surgery Department Head and Neck and Skull Base Surgery Center, King Abdullah Medical City Makkah Saudi Arabia"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"29","key":"e_1_2_11_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12200"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ATMR.ATMR_66_24"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420927244"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0152ED"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29527"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.77804"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13040430"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjoh.sjoh_37_25"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-02062-x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14010003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924251313493"},{"issue":"9","key":"e_1_2_11_15_1","first-page":"e114","article-title":"Dupilumab versus omalizumab in patients with chronic rhinosinusitis with nasal polyps and coexisting asthma (EVEREST): a multicentre, randomised, double\u2010blind, parallel\u2010group, phase 3 trial","volume":"13","author":"De Corso E","year":"2025","journal-title":"Lancet Respir Med"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/immuno5030026"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16499"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31948"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519228"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00823-1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/pajr.pajr_27_20"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2024.00233"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","unstructured":"HigginsJP GreenS eds.Cochrane Handbook for Systematic Reviews of Interventions. 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