{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:03:59Z","timestamp":1785344639428,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study evaluated the use of narrow\u2010band imaging (NBI) to assist in achieving adequate excision of oral leukoplakia with complete removal of lesions. Use of lidocaine combined with a vasoconstrictor for local anesthesia is standard practice in surgery. However, the blanching effect that follows injection can obscure the boundary between oral leukoplakia and the surrounding normal mucosa. A two\u2010stage local anesthesia protocol was applied: plain lidocaine was first administered for anesthesia, after which the excision margin was defined under NBI illumination using a carbon dioxide laser, followed by lidocaine with epinephrine for resection. Twenty\u2010one patients (18 men, 3 women) with 50 lesions were treated. All surgical margins were free of residual disease. During at least 12 months of follow\u2010up, one recurrence occurred, and no malignant transformations were observed. In conclusion, NBI\u2010guided excision with two\u2010stage local anesthesia avoids the blanching effect and enhances visualization, facilitates precise margin delineation, and supports complete lesion removal.<\/jats:p>","DOI":"10.1002\/ohn.70302","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:55:48Z","timestamp":1779458148000},"page":"492-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Image\u2010Guided Excision of Oral Leukoplakia Using Narrow\u2010Band Imaging Illumination and Two\u2010Stage Local Anesthesia"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-7912","authenticated-orcid":false,"given":"Shih\u2010Wei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Chang Gung Memorial Hospital Keelung Taiwan Republic of China"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.08.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23629"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.01.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.07.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2006.09.006"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:56:37Z","timestamp":1785344197000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ohn.70302"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70302","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}