{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:16:03Z","timestamp":1788030963664,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,9]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate the influence of auditory deprivation on sequential cochlear implants in postlingual patients, comparing the ear with shorter deprivation (ESAD), longer deprivation (ELAD), and the bilateral condition (BIL).<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n A tertiary referral center.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Postlingually deafened patients who underwent sequential bilateral implantation between 1990 and 2021. Auditory performance was assessed over 24 months after activation of each implant. Outcomes included free\u2010field pure\u2010tone average (PTA), speech detection threshold (SDT), and sentence recognition in quiet and in noise at +10\u2009dB SNR. Secondary variables were interimplant interval, duration of preimplant hearing aid use, etiology, and electrode insertion depth.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n ESAD outperformed ELAD in quiet (73% [IQR 44\u201092] vs 37% [IQR 0\u201087]) and in noise (27% [IQR 0\u201062] vs 0% [IQR 0\u201045]) at 24 months (\n P<\/jats:italic>\n \u2009<\u2009.001). BIL achieved superior results to both monaural conditions in quiet (97% [IQR 72.5\u2010100],\n P<\/jats:italic>\n \u2009<\u2009.001) and in noise (57% [IQR 23\u201086.5],\n P<\/jats:italic>\n \u2009=\u2009.008), regardless of ESAD experience. Interimplant interval correlated positively with BIL performance (\n r<\/jats:italic>\n \u2009=\u20090.450;\n P<\/jats:italic>\n \u2009<\u2009.001). Longer hearing aid use was negatively associated with ESAD (\n r<\/jats:italic>\n \u2009=\u2009\u22120.293;\n P<\/jats:italic>\n \u2009=\u2009.020) and BIL performance (\n r<\/jats:italic>\n \u2009=\u2009\u22120.312;\n P<\/jats:italic>\n \u2009=\u2009.018). Partial electrode insertion in ELAD was linked to poorer BIL outcomes in quiet (\n P<\/jats:italic>\n \u2009=\u2009.045). No correlations were found for age or etiology.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Shorter auditory deprivation and interimplant intervals are associated with better outcomes. Bilateral stimulation enhances performance even with long deprivation in 1 ear, and auditory experience with the first implant improves results. Complete insertion favors the more deprived ear, whereas prolonged ineffective hearing aid use may compromise outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ohn.70308","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:31:04Z","timestamp":1780489864000},"page":"672-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Asymmetric Auditory Deprivation in Sequential Cochlear Implant"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-140X","authenticated-orcid":false,"given":"Eduardo S.","family":"Farinazzo","sequence":"first","affiliation":[{"name":"Cochlear Implant Section and Department of Otolaryngology, Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens V.","family":"de Brito Neto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabete H.","family":"Yamaguti","sequence":"additional","affiliation":[{"name":"Cochlear Implant Section and Department of Otolaryngology, Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Fornazieri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz F. M.","family":"Louren\u00e7one","sequence":"additional","affiliation":[{"name":"Cochlear Implant Section and Department of Otolaryngology, Hospital for Rehabilitation of Craniofacial Anomalies University of S\u00e3o Paulo Bauru Brazil"},{"name":"Departament of Medicine Bauru School of Medicine\u2010FMBRU\/USP Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1044\/2014_AJA-13-0066"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.528"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32834fab4b"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001257"},{"key":"e_1_2_9_6_1","unstructured":"Brazilian Ministry of Health. Ordinance No. 2 Consolidation Ordinance No. 2\/GM\/MS (September 28 2017) incorporating the cochlear implant candidacy criteria established in Ordinance No. 2 776 (2014). Bras\u00edlia Brazil."},{"key":"e_1_2_9_7_1","unstructured":"OliveiraST.Avalia\u00e7\u00e3o da percep\u00e7\u00e3o de fala utilizando senten\u00e7as do dia a dia [dissertation]. S\u00e3o Paulo Brazil: Pontif\u00edcia Universidade Cat\u00f3lica de S\u00e3o Paulo;1992."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13193"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000988"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.102366"},{"key":"e_1_2_9_11_1","article-title":"Cortical plasticity in post\u2010lingually deafened adults with cochlear implants: a longitudinal fMRI study","volume":"30","author":"Sun Y","year":"2021","journal-title":"Neuroimage Clin"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"111","article-title":"Contribution of auditory brain plasticity to cochlear implant benefits: a review of animal studies","volume":"31","author":"Fallon JB","year":"2008","journal-title":"Trends Neurosci"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","DOI":"10.1177\/23312165241229880","article-title":"Review of binaural processing with asymmetrical hearing outcomes in patients with bilateral cochlear implants","volume":"28","author":"Anderson SR","year":"2024","journal-title":"Trends Hear"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1044\/2014_JSLHR-H-13-0087"},{"issue":"9","key":"e_1_2_9_15_1","first-page":"797","article-title":"Cochlear implantation in bacterial meningitis: a case series","volume":"135","author":"Alhabib S","year":"2021","journal-title":"J Laryngol Otol"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"1226","article-title":"Long\u2010term benefits of hearing aid use prior to cochlear implantation on speech perception","volume":"8","author":"Park HK","year":"2018","journal-title":"Sci Rep"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318184f492"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001125"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:37:34Z","timestamp":1788028654000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ohn.70308"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70308","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}