{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:39Z","timestamp":1791798579206,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate differences in clinicopathological characteristics, treatment strategies, and oncological outcomes between preoperatively diagnosed and undiagnosed major salivary gland cancers (MSGCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A single tertiary academic hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Surgically confirmed MSGCs between 2012 and 2023 were included. The cohort was divided into the diagnosed and undiagnosed groups based on the preoperative diagnosis of MSGC determined by fine\u2010needle aspiration cytology (FNAC) or core\u2010needle biopsy. Clinicopathologic features, surgical strategies, and loco\u2010regional control (LRC) were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 122 patients were enrolled. Among those, 49 (40.2%) were diagnosed preoperatively, while 73 (59.8%) were undiagnosed. The undiagnosed group had a higher reliance on FNAC (93.2% vs 51.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and higher proportions of low\/intermediate\u2010grade tumors (75% vs 26.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and mucoepidermoid carcinoma (45.2% vs 18.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). These were verified as independent risk factors for preoperative undiagnosis in multivariate logistic regression analysis. The undiagnosed group was associated with delayed (60 vs 24 days,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and more limited surgical procedures, including lower frequency of near\u2010total\/total parotidectomy (23.3% vs 42.9%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001) and elective neck dissection (26.5% vs 61.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), compared to the diagnosed group. Grade\u2010 and stage\u2010matched analysis showed a trend towards worse LRC in the high\u2010grade or advanced\u2010stage undiagnosed MSGCs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperatively undiagnosed MSGCs exhibit distinct clinicopathological characteristics, treatment strategies, and oncological outcomes compared to preoperatively diagnosed cases, highlighting the critical role of preoperative diagnosis in the management MSGCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70330","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:03:02Z","timestamp":1783346582000},"page":"881-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperatively Diagnosed Versus Undiagnosed Major Salivary Gland Cancer: Clinicopathological Characteristics, Treatment Strategies, and Oncological Outcomes"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-7406","authenticated-orcid":false,"given":"Dongbin","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, School of Medicine Kyungpook National University Daegu Korea"},{"name":"Gleiberman Head and Neck Cancer Center, Moores Cancer Center University of California San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Califano","sequence":"additional","affiliation":[{"name":"Gleiberman Head and Neck Cancer Center, Moores Cancer Center University of California San Diego La Jolla California USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California San Diego, School of Medicine San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, School of Medicine Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jae","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, School of Medicine Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Yup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, School of Medicine Kyungpook National University Daegu 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