{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:33Z","timestamp":1791798573485,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify clinical factors associated with laryngeal involvement in patients with angioedema and to validate a triage algorithm for determining the need for nasopharyngoscopic evaluation in the emergency department (ED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A retrospective review was performed of all patients presenting to the ED with angioedema or allergic reaction between 2014 and 2019 who underwent fiberoptic laryngeal (FOL) examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic, clinical, and endoscopic data were analyzed to identify predictors of positive FOL findings. A multivariable logistic regression model was developed and tested in an independent temporal validation cohort (2023\u20102025) using identical inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The derivation cohort included 540 patients, 46 (8.5%) of whom had laryngeal edema on FOL. Age\u2009&gt;50, shortness of breath, edematous uvula, and history of prior angioedema were independent predictors of laryngeal involvement, while lip swelling was protective. When the resulting triage algorithm was applied to the validation cohort (n\u2009=\u200943), 35 patients (81.4%) would have been managed without ENT referral; none required intubation or airway intervention. The algorithm correctly identified 79.5% of patients with a normal laryngeal examination and achieved an estimated 80% reduction in ENT consultations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A simple triage algorithm based on age, shortness of breath, uvular edema, prior episodes, and lip swelling may safely guide the need for nasopharyngoscopy in patients with angioedema. Temporal validation confirmed that the approach can markedly reduce unnecessary ENT consultations without compromising airway safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70338","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:46:15Z","timestamp":1783953975000},"page":"874-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Airway Risk in Angioedema: Validation of a Clinical Triage Algorithm for ENT Referral"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-1161","authenticated-orcid":false,"given":"Dan","family":"Yaniv","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Vainer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Dudkiewicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviram","family":"Mizrachi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Weill Cornell Medical College, Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Hamzani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Yosefof","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"},{"name":"Institute of Oncology, Davidoff Center Rabin Medical Center, Petach Tikva, Israel Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Granat","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv Israel"},{"name":"The Department of Emergency Medicine Rabin Medical Center Beilinson Hospital Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Bachar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rabin Medical Center Petach Tikva Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University, Tel Aviv, Israel  Tel Aviv 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