{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:49:41Z","timestamp":1791798581566,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the impact of surgical margin status and re\u2010resection on local recurrence (LR) in early\u2010stage oral cavity squamous cell carcinoma (OCSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective analysis of 352 patients with cT1\u20102N0 OCSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary care center from 2005 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were stratified by margin status: initial negative (n\u2009=\u2009325), re\u2010resected to negative (RRN) (n\u2009=\u200920), and positive (n\u2009=\u20097). Initial margin status was determined intraoperatively with frozen sections using specimen\u2010based or tumor bed\u2013based sampling. Primary outcome was 3\u2010year LR. Chi\u2010square tests and Cox proportional hazards models evaluated differences across groups, accounting for potential confounders, for example, adjuvant treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The most common subsite was the tongue (60.2%). 75.9% underwent elective neck dissection. 5.7% had an initial positive margin RRN. 4.8% and 22.7% received adjuvant chemoradiotherapy and radiotherapy, respectively. LR rates were 10.5% for initial negative, 35.0% for RRN, and 42.9% for positive margins despite re\u2010resection. Compared to patients with initial negative, those with positive (hazard ratio [HR] 5.67, 95% CI 1.74\u201018.61) and RRN (HR 3.32, 95% CI 1.47\u20107.49) margins showed higher rates of LR. There was no significant difference in LR rates between positive versus RRN margins (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u2009.374). After controlling for adjuvant therapy and margin assessment method, positive (aHR 8.32, 95% CI 2.31\u201029.9) and RRN (aHR 3.82, 95% CI 1.68\u20108.68) margins remained associated with higher LR. Adjuvant therapy trended toward a protective effect (aHR 0.53, 95% CI 0.24\u20101.17,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.117).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RRN margins should not be considered oncologically equivalent to initial negative margins, as demonstrated by higher 3\u2010year LR rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70343","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:14:14Z","timestamp":1784808854000},"page":"890-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Margin Status and Local Recurrence in Early\u2010Stage Oral\u2010Cavity Squamous Cell Carcinoma: Analysis of Reresection Outcomes"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-6858","authenticated-orcid":false,"given":"Hannah J.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Alapati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameen M.","family":"Amanian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-6453","authenticated-orcid":false,"given":"Andr\u00e9s M.","family":"Bur","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21565"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0378-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0113"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30458-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80555-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.10.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9761-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.08.014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23110"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502163320704"},{"key":"e_1_2_9_16_1","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: head and neck cancers. National Comprehensive Cancer Network; 2013."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105499"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21349"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21334"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107046"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819839006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106402"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2008.04791.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0262"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9761-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00290-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.784924"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14129"},{"issue":"10","key":"e_1_2_9_29_1","first-page":"749","article-title":"Frequency of p53 gene mutation and protein expression in oral squamous cell carcinoma","volume":"24","author":"Ara N","year":"2014","journal-title":"J Coll Phys Surg Pak"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001306"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112635"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.123239"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.1351"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.013"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.2982"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X221101024"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.11.010"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:30:09Z","timestamp":1791797409000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ohn.70343"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70343","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}