{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:29:01Z","timestamp":1786969741607,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Malignant salivary gland tumors represent a heterogeneous group of neoplasms with variable management. This study evaluated trends in therapeutic approaches to these cancers to inform evidence\u2010based, personalized care and optimize patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Population\u2010based analysis using the Surveillance, Epidemiology, and End Results (SEER) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases of malignant salivary gland tumors diagnosed between 2000 and 2021 were categorized by treatment modality and stage at diagnosis. Trends over time were assessed using JoinPoint segmented log\u2010linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 24,029 patients were included. Surgery alone (36.3%) and surgery with adjuvant radiation (36.5%) comprised the majority of treatments. Chemotherapy alone increased significantly over time (annual percent change [APC] +5.81%; 95% CI, 3.46\u20109.24;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05), though it remained infrequently used. Combined modalities including surgery, chemotherapy, and radiation also showed modest growth over the study period. Stage analysis revealed increasing proportions of localized and regional tumors and a decline in distant disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgery remains the cornerstone of malignant salivary gland tumor management, but use of combined treatment approaches is rising, likely reflecting advances in systemic therapies and radiation techniques. Awareness of these trends is critical for guiding multidisciplinary, personalized care. Future studies integrating clinical outcomes and histologic subtype are warranted to clarify the role of expanding systemic and combined modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70375","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:12:11Z","timestamp":1786968731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Malignant Salivary Gland Tumors: A 20\u2010Year SEER Database Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4776-3360","authenticated-orcid":false,"given":"Christopher","family":"Stewart","sequence":"first","affiliation":[{"name":"School of Medicine Joplin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JB","family":"Eyring","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Salt Lake City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braxton","family":"Felix","sequence":"additional","affiliation":[{"name":"School of Medicine Joplin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karson","family":"Ballard","sequence":"additional","affiliation":[{"name":"School of Medicine Joplin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Pham","sequence":"additional","affiliation":[{"name":"School of Medicine Joplin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy","family":"Gotti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Joplin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Joplin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McClintick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Joplin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"McIntire","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Joplin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s12105-022-01459-0","article-title":"Distribution and frequency of salivary gland tumours: an international multicenter study","volume":"16","author":"Alsanie I","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"2","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/srmjrds.srmjrds_57_17","article-title":"A demographic study of salivary gland tumors","volume":"9","author":"Sardar M","year":"2018","journal-title":"SRM J Res Dent Sci"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"597","article-title":"The evolving landscape of salivary gland tumors","volume":"73","author":"Steuer CE","year":"2023","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.semdp.2023.04.010","article-title":"Salivary gland neoplasms in small biopsies and fine needle aspirations","volume":"40","author":"Jalaly JB","year":"2023","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1264287","article-title":"Current management and future challenges in salivary glands cancer","volume":"13","author":"Locati LD","year":"2023","journal-title":"Front Oncol"},{"issue":"3","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11030720","article-title":"Targeted therapy, chemotherapy, immunotherapy and novel treatment options for different subtypes of salivary gland cancer","volume":"11","author":"Mueller SK","year":"2022","journal-title":"J Clin Med"},{"key":"e_1_2_9_8_1","unstructured":"Race and Hispanic Ethnicity Changes\u2014SEER Documentation. SEER. Accessed January 1 2026.https:\/\/seer.cancer.gov\/seerstat\/variables\/seer\/race_ethnicity\/index.html"},{"key":"e_1_2_9_9_1","unstructured":"Summary Staging Manual\u20142018. SEER. Accessed January 1 2026.https:\/\/seer.cancer.gov\/tools\/ssm\/index.html"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.21.00449","article-title":"Management of salivary gland malignancy: ASCO guideline","volume":"39","author":"Geiger JL","year":"2021","journal-title":"J Clin Oncol"},{"issue":"4","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.3390\/curroncol32040232","article-title":"Advances in targeted and systemic therapy for salivary gland carcinomas: current options and future directions","volume":"32","author":"Sreenivasan S","year":"2025","journal-title":"Curr Oncol"},{"issue":"6","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/lary.32003","article-title":"18F\u2010FDG PET\/CT for surveillance in salivary gland cancers: a systematic review and meta\u2010anaysis","volume":"135","author":"Ajit\u2010Roger E","year":"2025","journal-title":"Laryngoscope"},{"issue":"6","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11912-019-0799-x","article-title":"Changes in the 8th edition of the American Joint Committee on Cancer (AJCC) staging of head and neck cancer: rationale and implications","volume":"21","author":"Zanoni DK","year":"2019","journal-title":"Curr Oncol Rep"},{"issue":"4","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/cncr.23626","article-title":"Parotid cancer: impact of changes from the 1997 to the 2002 American Joint Committee on Cancer classification on outcome prediction","volume":"113","author":"Schroeder U","year":"2008","journal-title":"Cancer"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ohn.70375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ohn.70375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:12:13Z","timestamp":1786968733000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1002\/ohn.70375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":13,"alternative-id":["10.1002\/ohn.70375"],"URL":"https:\/\/doi.org\/10.1002\/ohn.70375","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ohn.70375"}}