{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:06:12Z","timestamp":1789589172679,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Robin sequence (RS) is an anomaly of micrognathia, glossoptosis, and airway obstruction. This study aims to assess the role of ankyloglossia as a protective factor in infants with RS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Single institution and population\u2010based inpatient registry analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective 15\u2010year single\u2010institution chart review examined medical records of infants with RS at an urban tertiary care center. Data included patient characteristics, comorbidities\/complications, airway interventions, and length of stay (LOS). Conclusions from this smaller sample were compared with analyses from a larger, less detailed, population\u2010based inpatient registry using the Kids' Inpatient Database (2016 and 2019). To quantify associations between patient characteristics and interventions and ankyloglossia, prevalence rates and unadjusted and adjusted odds ratios (ORs) were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the single\u2010institution analysis, five (8.8%) of 57 infants with RS had ankyloglossia. Ankyloglossia was negatively associated with hypoventilation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.024), need for airway intervention (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), number of airway interventions (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and total and NICU LOS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001). In the nationwide analysis, 45 (3.7%) of 1207 weighted hospital births with RS had ankyloglossia. Ankyloglossia was negatively associated with respiratory failure of newborn in both univariate and multivariate analysis (unadjusted OR 0.44,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.027; adjusted OR 0.19,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005), as well as need for mechanical ventilation in univariate analysis (unadjusted OR 0.39,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In infants with RS, ankyloglossia may be protective against hypoventilation, mechanical ventilation, and the need for airway intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ohn.70381","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:17:56Z","timestamp":1786969076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Ankyloglossia as a Protective Factor in Management of Infants With Robin Sequence"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-7547","authenticated-orcid":false,"suffix":"III","given":"David","family":"O'Neil Danis","sequence":"first","affiliation":[{"name":"Dr. Elie E. Rebeiz Department of Otolaryngology\u2013Head and Neck Surgery Tufts Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Steinwald","sequence":"additional","affiliation":[{"name":"Dr. Elie E. Rebeiz Department of Otolaryngology\u2013Head and Neck Surgery Tufts Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-3396","authenticated-orcid":false,"given":"Andrew R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Dr. Elie E. Rebeiz Department of Otolaryngology\u2013Head and Neck Surgery Tufts Medical Center Boston Massachusetts USA"},{"name":"Tufts University School of Medicine Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814542759"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0998-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.16"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200307000-00011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.11.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001688"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2018.11.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1992_029_0224_moaoir_2.3.co_2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.0948"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510391052"},{"issue":"5","key":"e_1_2_9_12_1","first-page":"1066","article-title":"Partial airway obstruction after lingual frenotomy","volume":"80","author":"Walsh F","year":"1995","journal-title":"Anesth Analg"},{"key":"e_1_2_9_13_1","unstructured":"Hoover\u2010FongJ MackayD ScottA. 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